Normal Regulatory α/β T Cells Effectively Eliminate Abnormally Activated T Cells Lacking the Interleukin 2 Receptor β in Vivo

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes

1999 • 269 citations

Interleukin 2 and its receptors: recent advances and new immunological functions

1996 • 241 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activitiesin vitro

1998 • 202 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 194 citations

Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor.

1997 • 192 citations

Specific Suppression of Human CD4+ Th Cell Responses to Pig MHC Antigens by CD8+CD28− Regulatory T Cells

1998 • 188 citations

Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing Vβ8 TCR: a role of the Qa-1 molecule

1995 • 175 citations

The Common γ-Chain for Multiple Cytokine Receptors

1995 • 168 citations

CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice

1998 • 159 citations

Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and ‐4

1994 • 146 citations

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene.

1995 • 145 citations

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death

1998 • 141 citations

T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8⁺T cells

1998 • 140 citations

Induction or Protection from Experimental Autoimmune Encephalomyelitis Depends on the Cytokine Secretion Profile of TCR Peptide-Specific Regulatory CD4 T Cells

1998 • 81 citations

Suppression of Immune Responses by CD8 Cells. I. Superantigen-Activated CD8 Cells Induce Unidirectional Fas-Mediated Apoptosis of Antigen-Activated CD4 Cells

1998 • 58 citations

Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice

1997 • 45 citations

Human suppressor T cells: Induction, differentiation, and regulatory functions

1986 • 26 citations

Molecular Events in the T Cell‐Mediated Suppression of the Immune Response

1991 • 9 citations

Suppression of Tumour‐Specific Cytotoxic T‐Cell Responses Against the Syngeneic BALB/c Plasmacytoma ADJ‐PC‐5 by Tumour‐Induced CD8⁺ Regulatory T Cells Via IFN‐γ

1996 • 6 citations

Suppression of immune responses by cloned T cells and their products.

1992 • 5 citations