Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Cytokine receptor signalling

1995 • 1,242 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

T Cell Activation and the Cytoskeleton

2000 • 264 citations

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

1994 • 210 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.

1985 • 162 citations

Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors

2000 • 153 citations

Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and ‐4

1994 • 146 citations

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death

1998 • 141 citations

Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

1986 • 106 citations

Interleukin 2 upregulates expression of its receptor on a T cell clone.

1985 • 102 citations

CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.

1998 • 97 citations

The Involvement of Interleukin (IL)-15 in Regulating the Differentiation of Granulated Metrial Gland Cells in Mouse Pregnant Uterus

1996 • 96 citations

Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.

1993 • 95 citations

The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit.

1987 • 91 citations

The Structure and Function of γс-Dependent Cytokines and Receptors: Regulation of T Lymphocyte Development and Homeostasis

1998 • 88 citations

In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells

1977 • 87 citations

CD4+ and CD8+ T Cell Interactions in IFN-γ and IL-4 Responses to Viral Infections: Requirements for IL-2

1998 • 85 citations

The murine IL 2 receptor. III. Cellular requirements for the induction of IL 2 receptor expression on T cell subpopulations.

1985 • 79 citations

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4

1995 • 66 citations

The murine IL 2 receptor. II. Monoclonal anti-IL 2 receptor antibodies as specific inhibitors of T cell function in vitro.

1984 • 65 citations

Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of alloreactive cytolytic T cells.

1981 • 60 citations

Role of Costimulation in the Induction of the IL-12/IL-12 Receptor Pathway and the Development of Autoimmunity

2000 • 59 citations

Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.

1996 • 46 citations

IL-2-Independent Activation and Proliferation in Human T Cells Induced by CD28

1999 • 35 citations

The Murine Interleukin‐2 Receptor: Biochemical Structure and Regulation of Expression

1986 • 32 citations

Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules.

1996 • 31 citations

Lymphokine Regulation of Activation-Induced Apoptosis in T Cells of IL-2 and IL-2Rβ Knockout Mice

1998 • 27 citations