Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

Innate Immune Recognition

2002 • 8,157 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Effector and memory T-cell differentiation: implications for vaccine development

2002 • 1,757 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

A Role for CD40 Expression on CD8 ⁺ T Cells in the Generation of CD8 ⁺ T Cell Memory

2002 • 629 citations

Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses

2002 • 402 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Induction of CD8⁺ T cells using heterologous prime‐boost immunisation strategies

1999 • 177 citations

A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge

1993 • 176 citations

Role of CD4 T Cell Help and Costimulation in CD8 T Cell Responses During Listeria monocytogenes Infection

2003 • 168 citations

Diminished Primary and Secondary Influenza Virus-Specific CD8⁺T-Cell Responses in CD4-Depleted Ig^−/−Mice

2000 • 142 citations

Postexposure vaccination massively increases the prevalence of γ-herpesvirus-specific CD8⁺T cells but confers minimal survival advantage on CD4-deficient mice

2000 • 49 citations

Reduced Functional Capacity of CD8+ T Cells Expanded by Post-Exposure Vaccination of γ-Herpesvirus-Infected CD4-Deficient Mice

2002 • 40 citations

A novel helper role for CD4 T cells

2000 • 33 citations