COMPARTMENTALIZED RAS/MAPK SIGNALING

Functional rafts in cell membranes

1997 • 9,471 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

ras GENES

1987 • 3,818 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Antigen Presentation and T Cell Stimulation by Dendritic Cells

2002 • 1,860 citations

The Guanine Nucleotide-Binding Switch in Three Dimensions

2001 • 1,779 citations

Lipid Rafts

2003 • 1,485 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

LAT

1998 • 1,251 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

2003 • 1,115 citations

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

2002 • 1,070 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains

1996 • 1,006 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

2005 • 886 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Phospholipids undergo hop diffusion in compartmentalized cell membrane

2002 • 878 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

LAT Palmitoylation

1998 • 837 citations

Signal transduction and endocytosis: close encounters of many kinds

2002 • 820 citations

An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

2005 • 816 citations

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

2001 • 808 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 • 799 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Endomembrane Trafficking of Ras

1999 • 753 citations

Single-Molecule Microscopy Reveals Plasma Membrane Microdomains Created by Protein-Protein Networks that Exclude or Trap Signaling Molecules in T Cells

2005 • 748 citations

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

1981 • 736 citations

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

2003 • 728 citations

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

2002 • 724 citations

Protein Prenyltransferases

1996 • 693 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

The β ₂ -adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

1999 • 615 citations

Ras signalling on the endoplasmic reticulum and the Golgi

2002 • 612 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1

2001 • 556 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

An Unidentified Virus which causes the Rapid Production of Tumours in Mice

1964 • 535 citations

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

2001 • 525 citations

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

2000 • 492 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

2003 • 462 citations

PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-Xl on Mitochondria and Induces Apoptosis

2006 • 454 citations

The role of lipid rafts in T cell antigen receptor (TCR) signalling

2000 • 453 citations

Identification of a Ras Palmitoyltransferase inSaccharomyces cerevisiae

2002 • 438 citations

Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes

1996 • 434 citations

Direct Pathway from Early/Recycling Endosomes to the Golgi Apparatus Revealed through the Study of Shiga Toxin B-fragment Transport

1998 • 425 citations

Distinct requirements for Ras oncogenesis in human versus mouse cells

2002 • 425 citations

H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway

2000 • 421 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

1980 • 404 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

2003 • 400 citations

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1999 • 397 citations

Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis and Intracellular Trafficking

2001 • 386 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

A Neurotrophin Signaling Cascade Coordinates Sympathetic Neuron Development through Differential Control of TrkA Trafficking and Retrograde Signaling

2004 • 381 citations

Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction

2002 • 375 citations

Integration of calcium and RAS signalling

2002 • 375 citations

Single-molecule imaging analysis of Ras activation in living cells

2004 • 369 citations

Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms

2003 • 359 citations

Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma.

1994 • 356 citations

Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis

1997 • 351 citations

The EGF receptor: a nexus for trafficking and signaling

2000 • 346 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

NGF Signaling from Clathrin-Coated Vesicles

2001 • 340 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking

2001 • 316 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Regulated Migration of Epidermal Growth Factor Receptor from Caveolae

1999 • 314 citations

The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction

1995 • 312 citations

Cell Surface Trk Receptors Mediate NGF-Induced Survival While Internalized Receptors Regulate NGF-Induced Differentiation

2000 • 311 citations

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1995 • 306 citations

Identification of Sef, a novel modulator of FGF signalling

2002 • 306 citations

Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling

2002 • 303 citations

Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.

1981 • 302 citations

Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

2000 • 301 citations

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

2004 • 299 citations

TGFβ receptor internalization into EEA1-enriched early endosomes

2002 • 298 citations

Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains

1998 • 291 citations

Endosomal Signaling of Epidermal Growth Factor Receptor Stimulates Signal Transduction Pathways Leading to Cell Survival

2002 • 289 citations

Mammalian Prenylcysteine Carboxyl Methyltransferase Is in the Endoplasmic Reticulum

1998 • 286 citations

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway

2005 • 281 citations

Sef Is a Spatial Regulator for Ras/MAP Kinase Signaling

2004 • 280 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1

2001 • 277 citations

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999 • 275 citations

Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo

2002 • 264 citations

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1997 • 252 citations

Nerve Growth Factor Activates Persistent Rap1 Signaling in Endosomes

2001 • 242 citations

Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1

2000 • 239 citations

The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15

1999 • 236 citations

Ras plasma membrane signalling platforms

2005 • 233 citations

Endocytosis of Functional Epidermal Growth Factor Receptor-Green Fluorescent Protein Chimera

1998 • 228 citations

Membrane rafts and signaling by the multichain immune recognition receptors

2000 • 226 citations

Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

2004 • 221 citations

Membranes as messengers in T cell adhesion signaling

2004 • 220 citations

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts

2003 • 206 citations

Identification of Constitutive and Ras-Inducible Phosphorylation Sites of KSR: Implications for 14-3-3 Binding, Mitogen-Activated Protein Kinase Binding, and KSR Overexpression

1999 • 205 citations

A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells

2005 • 201 citations

Phosphorylation of Y845 on the Epidermal Growth Factor Receptor Mediates Binding to the Mitochondrial Protein Cytochrome c Oxidase Subunit II

2004 • 197 citations

Fluorescence lifetime imaging of receptor tyrosine kinase activity in cells

1999 • 192 citations

Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

2004 • 189 citations

Signaling endosome hypothesis: A cellular mechanism for long distance communication

2003 • 188 citations

Coordinated Traffic of Grb2 and Ras during Epidermal Growth Factor Receptor Endocytosis Visualized in Living Cells

2002 • 186 citations

Long-distance retrograde neurotrophic signaling

2005 • 183 citations

Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells

1999 • 179 citations

Ras regulation and function in lymphocytes

2000 • 179 citations

Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion

2004 • 169 citations

Cbl-dependent Ubiquitination Is Required for Progression of EGF Receptors into Clathrin-coated Pits

2004 • 167 citations

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

1999 • 165 citations

Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane

2004 • 154 citations

Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.

1991 • 149 citations

Involvement of a Mitochondrial Phosphatase in the Regulation of ATP Production and Insulin Secretion in Pancreatic β Cells

2005 • 147 citations

Ras Activation in Jurkat T cells following Low-Grade Stimulation of the T-Cell Receptor Is Specific to N-Ras and Occurs Only on the Golgi Apparatus

2004 • 145 citations

Exchange Factors of the RasGRP Family Mediate Ras Activation in the Golgi

2003 • 144 citations

Compartmentalized signal transduction by receptor tyrosine kinases

1995 • 144 citations

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin

2005 • 140 citations

Diacylglycerol-dependent Binding Recruits PKCθ and RasGRP1 C1 Domains to Specific Subcellular Localizations in Living T Lymphocytes

2004 • 138 citations

H-Ras Signaling and K-Ras Signaling Are Differentially Dependent on Endocytosis

2002 • 137 citations

Interactions of Cbl with Two Adaptor Proteins, Grb2 and Crk, upon T Cell Activation

1996 • 136 citations

The Cbl Family and Other Ubiquitin Ligases

2004 • 133 citations

Immature Thymocytes Employ Distinct Signaling Pathways for Allelic Exclusion versus Differentiation and Expansion

1999 • 120 citations

Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions

2005 • 114 citations

Isolated endosomes from quiescent rat liver contain the signal transduction machinery

1998 • 104 citations

CAPRI regulates Ca2+-dependent inactivation of the Ras-MAPK pathway

2001 • 102 citations

Multivesicular Bodies and Multivesicular Endosomes: The "Ins and Outs" of Endosomal Traffic

2002 • 101 citations

Activation of H-Ras in the Endoplasmic Reticulum by the RasGRF Family Guanine Nucleotide Exchange Factors

2004 • 98 citations

The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain

2000 • 94 citations

The odd couple: signal transduction and endocytosis

2003 • 91 citations

Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways

2000 • 90 citations

Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of ras (KSR)

2002 • 89 citations

Protein Kinase D1 and the β1 Integrin Cytoplasmic Domain Control β1 Integrin Function via Regulation of Rap1 Activation

2005 • 87 citations

Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells

2003 • 87 citations

Palmitoylation and Plasma Membrane Localization of Ras2p by a Nonclassical Trafficking Pathway in Saccharomyces cerevisiae

2003 • 85 citations

Real Time Fluorescence Imaging of Plcγ Translocation and Its Interaction with the Epidermal Growth Factor Receptor

2001 • 81 citations

Erf4p and Erf2p Form an Endoplasmic Reticulum-associated Complex Involved in the Plasma Membrane Localization of Yeast Ras Proteins

2002 • 79 citations

Membrane Insertion of a Lipidated Ras Peptide Studied by FTIR, Solid-State NMR, and Neutron Diffraction Spectroscopy

2003 • 77 citations

Nucleotide sequence of the two rat cellular rasH genes.

1986 • 75 citations

RETRACTED: Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1

2003 • 74 citations

Two Ras Pathways in Fission Yeast Are Differentially Regulated by Two Ras Guanine Nucleotide Exchange Factors

2002 • 74 citations

Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: Implications in prevention of apoptosis

1999 • 73 citations

Intersectin, an Adaptor Protein Involved in Clathrin-mediated Endocytosis, Activates Mitogenic Signaling Pathways

2000 • 68 citations

Yeast Ras Regulates the Complex that Catalyzes the First Step in GPI-Anchor Biosynthesis at the ER

2004 • 66 citations

Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF

2001 • 63 citations

Intersectin Activates Ras but Stimulates Transcription through an Independent Pathway Involving JNK

2003 • 63 citations

Transgenic analysis of thymocyte signal transduction

2002 • 57 citations

Mice deficient for N-ras: impaired antiviral immune response and T-cell function.

2003 • 53 citations

T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse

2004 • 45 citations

EGF-Dependent Translocation of Green Fluorescent Protein-Tagged PLC-γ1 to the Plasma Membrane and Endosomes

2001 • 43 citations

Ras-Independent Activation of ERK Signaling via the Torso Receptor Tyrosine Kinase Is Mediated by Rap1

2005 • 41 citations

A Novel Ras Inhibitor, Eri1, Engages Yeast Ras at the Endoplasmic Reticulum

2003 • 37 citations

Probing the role of loop 2 in Ras function with unnatural amino acids.

1993 • 37 citations

Scaffolding and protein interactions in MAP kinase modules

1999 • 32 citations