Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

2001 • 808 citations

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 • 675 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1

2001 • 556 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

2000 • 494 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis and Intracellular Trafficking

2001 • 386 citations

Endocytosis and Signaling

2001 • 377 citations

Quantitative Imaging of Lateral ErbB1 Receptor Signal Propagation in the Plasma Membrane

2000 • 346 citations

Signal transduction: hanging on a scaffold

2000 • 341 citations

NGF Signaling from Clathrin-Coated Vesicles

2001 • 340 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 314 citations

The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor

1999 • 308 citations

Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

2000 • 301 citations

Regulation of signal transduction by endocytosis

2000 • 299 citations

C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1

2001 • 277 citations

Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer

1999 • 264 citations

KSR modulates signal propagation within the MAPK cascade.

1996 • 252 citations

Nerve Growth Factor Activates Persistent Rap1 Signaling in Endosomes

2001 • 242 citations

Why cytoplasmic signalling proteins should be recruited to cell membranes

2000 • 235 citations

Mitogen-activated protein kinases

2002 • 232 citations

Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

2000 • 216 citations

KSR is a scaffold required for activation of the ERK/MAPK module

2002 • 215 citations

Sorting in the endosomal system in yeast and animal cells

2000 • 211 citations

Identification of Constitutive and Ras-Inducible Phosphorylation Sites of KSR: Implications for 14-3-3 Binding, Mitogen-Activated Protein Kinase Binding, and KSR Overexpression

1999 • 205 citations

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK

1998 • 196 citations

A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment

2001 • 196 citations

Fluorescence lifetime imaging of receptor tyrosine kinase activity in cells

1999 • 192 citations

Coordinated Traffic of Grb2 and Ras during Epidermal Growth Factor Receptor Endocytosis Visualized in Living Cells

2002 • 186 citations

Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p

1995 • 173 citations

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

1999 • 165 citations

Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase.

1995 • 147 citations

Endocytosis and mitogenic signaling

1999 • 131 citations

Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11

1998 • 110 citations

Endocytosis and signaling cascades: a close encounter

2001 • 105 citations

MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?

2002 • 100 citations

MAP Kinase Module: The Ksr Connection

2002 • 31 citations

Scaffold protein regulation of mitogen-activated protein kinase cascade

2001 • 17 citations