H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway

Functional rafts in cell membranes

1997 • 9,471 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

ER-to-Golgi transport visualized in living cells

1997 • 1,169 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Endomembrane Trafficking of Ras

1999 • 753 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

The plasma membrane

1983 • 561 citations

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

1997 • 537 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase

1998 • 475 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

1999 • 456 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis

1997 • 351 citations

Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides

1995 • 350 citations

Caveolin-3 Associates with Developing T-tubules during Muscle Differentiation

1997 • 345 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Vesicular Tubular Clusters between the ER and Golgi Mediate Concentration of Soluble Secretory Proteins by Exclusion from COPI-Coated Vesicles

1999 • 320 citations

Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.

1993 • 318 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Mammalian Prenylcysteine Carboxyl Methyltransferase Is in the Endoplasmic Reticulum

1998 • 286 citations

Separation of “Glycosphingolipid Signaling Domain” from Caveolin-containing Membrane Fraction in Mouse Melanoma B16 Cells and Its Role in Cell Adhesion Coupled with Signaling

1998 • 284 citations

Fluorometric Evaluation of the Affinities of Isoprenylated Peptides for Lipid Bilayers

1994 • 253 citations

Control of the ERK MAP kinase cascade by Ras and Raf.

1996 • 249 citations

The murine N-ras gene is not essential for growth and development.

1995 • 236 citations

Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain

1998 • 232 citations

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.

1994 • 230 citations

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.

1991 • 230 citations

Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells

1999 • 179 citations

Ras effectors and their role in mitogenesis and oncogenesis

1997 • 167 citations

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

1994 • 165 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein.

1990 • 161 citations

Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease

1999 • 161 citations

Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger

1997 • 117 citations

Prenylation-dependent Association of Ki-Ras with Microtubules

1997 • 117 citations

Membrane Interactions of a Constitutively Active GFP-Ki-Ras 4B and Their Role in Signaling

1999 • 117 citations

Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae.

1990 • 115 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Proteinin Vivo

1998 • 91 citations

Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

1998 • 73 citations

Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

1997 • 67 citations

A Non-farnesylated Ha-Ras Protein Can Be Palmitoylated and Trigger Potent Differentiation and Transformation

1999 • 63 citations

Trafficking of an Acylated Cytosolic Protein: Newly Synthesized p56lck Travels to the Plasma Membrane via the Exocytic Pathway

1999 • 59 citations

A polybasic domain allows nonprenylated Ras proteins to function in Saccharomyces cerevisiae.

1994 • 47 citations

Microsomal membranes contain a high affinity binding site for prenylated peptides

1993 • 42 citations

[24] Prenylation and palmitoylation analysis

1995 • 34 citations

Translocation of Ki-ras P21 between Membrane and Cytoplasm by smg GDS

1993 • 23 citations