Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis

Protein Sorting by Transport Vesicles

1996 • 1,168 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

Chemical structure of the hexapeptide chromophore of the Aequorea green-fluorescent protein

1993 • 648 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1995 • 533 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

1992 • 380 citations

Functional homology of mammalian and yeast RAS genes

1985 • 324 citations

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

1992 • 306 citations

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1991 • 291 citations

[5] Assay of yeast mating reaction

1991 • 286 citations

Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast.

1994 • 265 citations

Lipid modifications of G proteins

1994 • 206 citations

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

1992 • 180 citations

Inhibitors of ras farnesyltransferases

1993 • 177 citations

Isoprenoid modification of rab proteins terminating in CC or CXC motifs.

1991 • 177 citations

Enzymatic Coupling of Cholesterol Intermediates to a Mating Pheromone Precursor and to the Ras Protein

1990 • 175 citations

RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.

1991 • 164 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.

1991 • 148 citations

Yeast peptide pheromones, a-factor and α-factor, activate a common response mechanism in their target cells

1986 • 137 citations

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.

1992 • 136 citations

Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export.

1994 • 110 citations

A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing steps.

1987 • 93 citations

Endoproteolytic processing of a farnesylated peptide in vitro.

1992 • 84 citations

Maturation of isoprenylated proteins in Saccharomyces cerevisiae. Multiple activities catalyze the cleavage of the three carboxyl-terminal amino acids from farnesylated substrates in vitro.

1992 • 72 citations

Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates

1992 • 70 citations

Characterization of a rat liver protein carboxyl methyltransferase involved in the maturation of proteins with the -CXXX C-terminal sequence motif.

1992 • 68 citations

Saccharomyces cerevisiae STE14 gene is required for COOH-terminal methylation of a-factor mating pheromone

1990 • 65 citations

Farnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometry.

1992 • 65 citations

Development of inhibitors of protein farnesylation as potential chemotherapeutic agents

1995 • 53 citations

Isoprenylation/Methylation of Proteins Enhances Membrane Association by a Hydrophobic Mechanism

1996 • 49 citations

Membrane translocation of proteins without hydrophobic signal peptides

1990 • 48 citations

A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide

1993 • 32 citations

Isolation and DNA sequence of the STE14 gene encoding farnesyl cysteine: Carboxyl methyltransferase

1993 • 31 citations

Isolation and characterization of temperature-sensitive mutations in the RAS2 and CYR1 genes of Saccharomyces cerevisiae.

1989 • 27 citations