Ras signalling on the endoplasmic reticulum and the Golgi

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

Endomembrane Trafficking of Ras

1999 • 753 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

1998 • 576 citations

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1

2001 • 556 citations

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase

1998 • 475 citations

H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway

2000 • 421 citations

Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

1980 • 404 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Selected glimpses into the activation and function of Src kinase

2000 • 402 citations

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

1996 • 328 citations

Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

2000 • 301 citations

Mammalian Prenylcysteine Carboxyl Methyltransferase Is in the Endoplasmic Reticulum

1998 • 286 citations

Imaging the intracellular trafficking and state of the AB5 quaternary structure of cholera toxin.

1996 • 286 citations

Four Human Ras Homologs Differ in Their Abilities to Activate Raf-1, Induce Transformation, and Stimulate Cell Motility

1999 • 285 citations

A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein.

1991 • 185 citations

Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

1998 • 185 citations

Differential Activation of the Rac Pathway by Ha-Ras and K-Ras

2001 • 171 citations

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

1994 • 165 citations

Endocytosis and mitogenic signaling

1999 • 131 citations

Phorbol esters modulate the Ras exchange factor RasGRP3.

2001 • 102 citations

[24] Biological assays for cellular transformation

1994 • 95 citations

In Vitro Tyrosine Phosphorylation of PLC-γ1 and PLC-γ2 by SRC-Family Protein Tyrosine Kinases

1993 • 89 citations

At reduced temperature, endocytic membrane traffic is blocked in multivesicular carrier endosomes in rat cardiac myocytes

1998 • 72 citations

Elevated Expression of Ets2 or Distinct Portions of Ets2 Can Reverse Ras-mediated Cellular Transformation

1998 • 50 citations

Activation of H-ras61L-Specific Signaling Pathways Does Not Require Posttranslational Processing of H-ras

2000 • 6 citations