Lipid Rafts

Functional rafts in cell membranes

1997 • 9,471 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

2002 • 2,231 citations

Cholesterol and the cell membrane

1985 • 1,465 citations

Lipid sorting in epithelial cells

1988 • 1,354 citations

The State of Lipid Rafts: From Model Membranes to Cells

2003 • 1,334 citations

Lipid Rafts Reconstituted in Model Membranes

2001 • 1,330 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

2002 • 1,130 citations

Phase equilibria of cholesterol/dipalmitoylphosphatidylcholine mixtures: deuterium nuclear magnetic resonance and differential scanning calorimetry

1990 • 1,100 citations

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 • 1,058 citations

Cholesterol interactions with phospholipids in membranes

2002 • 1,030 citations

Phase equilibria in the phosphatidylcholine-cholesterol system

1987 • 1,024 citations

The Immunological Synapse

2001 • 987 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

Interaction of membrane proteins and lipids with solubilizing detergents

2000 • 982 citations

Phospholipids undergo hop diffusion in compartmentalized cell membrane

2002 • 878 citations

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

2003 • 839 citations

LAT Palmitoylation

1998 • 837 citations

Membrane Structure: Some General Principles

1973 • 825 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

2003 • 728 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

Selective solubilization of proteins and phospholipids from red blood cell membranes by nonionic detergents

1973 • 687 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research

1999 • 622 citations

Ras signalling on the endoplasmic reticulum and the Golgi

2002 • 612 citations

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

2002 • 597 citations

How proteins move lipids and lipids move proteins

2001 • 562 citations

Crystal structure of cholera toxin B‐pentamer bound to receptor G_M1 pentasaccharide

1994 • 558 citations

Cholesterol Is Required for Surface Transport of Influenza Virus Hemagglutinin

1998 • 555 citations

Triton Promotes Domain Formation in Lipid Raft Mixtures

2002 • 547 citations

Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex

2001 • 525 citations

The differential miscibility of lipids as the basis for the formation of functional membrane rafts

1998 • 512 citations

Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts

1989 • 509 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Probing Lipid Mobility of Raft-exhibiting Model Membranes by Fluorescence Correlation Spectroscopy

2003 • 494 citations

Sphingolipid organization in biomembranes: what physical studies of model membranes reveal

1998 • 484 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

The concept of lipid domains in membranes.

1982 • 466 citations

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

1999 • 456 citations

Distribution of a Glycosylphosphatidylinositol-anchored Protein at the Apical Surface of MDCK Cells Examined at a Resolution of <100 Å Using Imaging Fluorescence Resonance Energy Transfer

1998 • 452 citations

High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes

2000 • 427 citations

Relationship of Lipid Rafts to Transient Confinement Zones Detected by Single Particle Tracking

2002 • 418 citations

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains

1998 • 415 citations

Organization of Glycosphingolipids in Bilayers and Plasma Membranes of Mammalian Cells

1985 • 395 citations

Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform

1997 • 388 citations

Caveosomes and endocytosis of lipid rafts

2003 • 386 citations

Aminophospholipid Asymmetry: A Matter of Life and Death

2003 • 384 citations

Lipid rafts in neuronal signaling and function

2002 • 383 citations

Endocytic Sorting of Lipid Analogues Differing Solely in the Chemistry of Their Hydrophobic Tails

1999 • 378 citations

Do sterols reduce proton and sodium leaks through lipid bilayers?

2001 • 373 citations

Water and nonelectrolyte permeability of lipid bilayer membranes.

1976 • 365 citations

Slow Diffusion of Proteins in the Yeast Plasma Membrane Allows Polarity to Be Maintained by Endocytic Cycling

2003 • 333 citations

Cholesterol Distribution in Living Cells: Fluorescence Imaging Using Dehydroergosterol as a Fluorescent Cholesterol Analog

1998 • 331 citations

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

2001 • 329 citations

The Organizing Potential of Sphingolipids in Intracellular Membrane Transport

2001 • 310 citations

Interaction of cholesterol with various glycerophospholipids and sphingomyelin

1990 • 310 citations

Somatic Mutations in Paroxysmal Nocturnal Hemoglobinuria: A Blessing in Disguise?

1997 • 305 citations

Vesicular and Non-vesicular Sterol Transport in Living Cells

2002 • 296 citations

Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment.

1995 • 294 citations

Cholesterol depletion induces large scale domain segregation in living cell membranes

2001 • 287 citations

Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth

1999 • 281 citations

Membrane properties of sphingomyelins

2002 • 274 citations

Phosphatidylcholine

1992 • 273 citations

Liquid-Liquid Immiscibility in Membranes

2003 • 261 citations

The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol.

1989 • 259 citations

Probing Red Cell Membrane Cholesterol Movement with Cyclodextrin

2002 • 245 citations

Translational Diffusion of Individual Class II MHC Membrane Proteinsin Cells

2002 • 241 citations

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

2002 • 220 citations

Glycosphingolipids Internalized via Caveolar-related Endocytosis Rapidly Merge with the Clathrin Pathway in Early Endosomes and Form Microdomains for Recycling

2003 • 216 citations

Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.

1991 • 213 citations

Effect of Cholesterol on the Water Permeability of Thin Lipid Membranes

1967 • 211 citations

The tyrosine kinase connection: how GPI-anchored proteins activate T cells

1993 • 198 citations

Dynamics of raft molecules in the cell and artificial membranes: approaches by pulse EPR spin labeling and single molecule optical microscopy

2003 • 192 citations

Effects of temperature and cholesterol on the glucose permeability of liposomes prepared with natural and synthetic lecithins

1968 • 181 citations

Structure and cohesive properties of sphingomyelin/cholesterol bilayers

1992 • 179 citations

Why do worms need cholesterol?

2003 • 178 citations

Long-Range Order in Biomembranes

1977 • 175 citations

Lipids of the Golgi membrane

1998 • 168 citations

Inositol Phosphorylceramide Synthase Is Located in the Golgi Apparatus ofSaccharomyces cerevisiae

2000 • 161 citations

Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies

2000 • 154 citations

Cholesterol Decreases the Interfacial Elasticity and Detergent Solubility of Sphingomyelins

2001 • 149 citations

Myelin glycolipids and their functions

1997 • 148 citations

Cholesterol Does Not Induce Segregation of Liquid-Ordered Domains in Bilayers Modeling the Inner Leaflet of the Plasma Membrane

2001 • 144 citations

Changes of membrane permeability due to extensive cholesterol depletion in mammalian erythrocytes

1974 • 143 citations

New perspectives on the function of myelin galactolipids

1998 • 132 citations

Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme

2002 • 124 citations

Regulation of band 3 mobilities in erythrocyte ghost membranes by protein association and cytoskeletal meshwork

1988 • 123 citations

Role of lipid rafts in Shiga toxin 1 interaction with the apical surface of Caco-2 cells

2001 • 122 citations

Apical targeting in polarized epithelial cells: There's more afloat than rafts

1997 • 118 citations

A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity

2001 • 112 citations

Lipid rafts and T cell receptor signaling: a critical re-evaluation

2002 • 106 citations

The use and abuse of filipin to localize cholesterol in membranes

1984 • 104 citations

Lipid Rafts and Assembly of Enveloped Viruses

2002 • 103 citations

Membrane fluidity and transport properties in epithelia

1992 • 103 citations

Changes in the spectral properties of a plasma membrane lipid analog during the first seconds of endocytosis in living cells

1997 • 98 citations

Simple method of purification of Escherichia coli heat-labile enterotoxin and cholera toxin using immobilized galactose

1994 • 93 citations

Monolayer coupling in sphingomyelin bilayer systems

1978 • 92 citations

Lateral diffusion in inhomogeneous membranes. Model membranes containing cholesterol

1980 • 85 citations

Reciprocal raft–receptor interactions and the assembly of adhesion complexes

2002 • 84 citations

Water Permeability of Asymmetric Planar Lipid Bilayers

2001 • 84 citations

Regulated Apical Secretion of Zymogens in Rat Pancreas

2001 • 78 citations

Lymphocyte lipid rafts: structure and function

2003 • 78 citations

Alteration of 86Rb+ influx and efflux following depletion of membrane sterol in L-cells.

1978 • 76 citations

A Model for Membrane Patchiness: Lateral Diffusion in the Presence of Barriers and Vesicle Traffic

1999 • 76 citations

Peering inside lipid rafts and caveolae

2002 • 70 citations

Lipid lateral diffusion in the surface membrane of cells and in multibilayers formed from plasma membrane lipids

1981 • 68 citations

Phase structures of binary lipid bilayers as revealed by permeability of small molecules

1998 • 68 citations

Patches and fences: probing for plasma membrane domains

1993 • 62 citations

Rapid Transbilayer Movement of Spin-Labeled Steroids in Human Erythrocytes and in Liposomes

2002 • 58 citations

Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol

1980 • 53 citations

Synergistic Assembly of Linker for Activation of T Cells Signaling Protein Complexes in T Cell Plasma Membrane Domains

2003 • 51 citations

Modulation of Pig Kidney Na⁺/K⁺-ATPase Activity by Cholesterol: Role of Hydration

2000 • 44 citations

Effects of membrane cholesterol manipulation on excitation‐contraction coupling in skeletal muscle of the toad

2001 • 41 citations