Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of ras (KSR)

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

1995 • 15,623 citations

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

Protein backbone angle restraints from searching a database for chemical shift and sequence homology.

1999 • 2,966 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

Correlating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMR

1992 • 1,012 citations

HNCACB, a High-Sensitivity 3D NMR Experiment to Correlate Amide-Proton and Nitrogen Resonances with the Alpha- and Beta-Carbon Resonances in Proteins

1993 • 797 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Correlation of Backbone Amide and Aliphatic Side-Chain Resonances in 13C/15N-Enriched Proteins by Isotropic Mixing of 13C Magnetization

1993 • 591 citations

1H1H correlation via isotropic mixing of 13C magnetization, a new three-dimensional approach for assigning 1H and 13C spectra of 13C-enriched proteins

1990 • 580 citations

A Gradient-Enhanced HCCH-TOCSY Experiment for Recording Side-Chain 1H and 13C Correlations in H2O Samples of Proteins

1993 • 471 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Taxonomy and function of C1 protein kinase C homology domains

1997 • 350 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 314 citations

The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction

1995 • 312 citations

Torsion-Angle Molecular Dynamics as a New Efficient Tool for NMR Structure Calculation

1997 • 308 citations

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1995 • 306 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

Tautomeric states of the active‐site histidines of phosphorylated and unphosphorylated III^Glc, a signal‐transducing protein from escherichia coli, using two‐dimensional heteronuclear NMR techniques

1993 • 294 citations

Release of Proteins and Peptides from Fusion Proteins Using a Recombinant Plant Virus Proteinase

1994 • 282 citations

An alternative 3D NMR technique for correlating backbone 15N with side chain Hβ resonances in larger proteins

1991 • 273 citations

KSR modulates signal propagation within the MAPK cascade.

1996 • 252 citations

EXAFS study of the zinc-binding sites in the protein transcription factor IIIA

1986 • 247 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

KSR: a MAPK scaffold of the Ras pathway?

2001 • 234 citations

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.

1994 • 221 citations

Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization

1999 • 214 citations

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.

1996 • 198 citations

Autoregulation of the Raf-1 serine/threonine kinase

1998 • 196 citations

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK

1998 • 196 citations

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

1996 • 193 citations

Controlled Intracellular Processing of Fusion Proteins by TEV Protease

2000 • 192 citations

ANSIG: A program for the assignment of protein 1H 2D NMR spectra by interactive computer graphics

1989 • 178 citations

The protein kinase KSR interacts with 14-3-3 protein and Raf

1997 • 175 citations

KSR stimulates Raf-1 activity in a kinase-independent manner

1997 • 166 citations

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

1995 • 157 citations

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

1998 • 151 citations

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

1996 • 140 citations

Solution structure of a cysteine rich domain of rat protein kinase C

1994 • 131 citations

NMR Structure of a Protein Kinase C-γ Phorbol-Binding Domain and Study of Protein−Lipid Micelle Interactions

1997 • 125 citations

An Intact Raf Zinc Finger Is Required for Optimal Binding to Processed Ras and for Ras-Dependent Raf Activation In Situ

1997 • 120 citations

Solution Structure of the Cysteine-rich Domain of the Escherichia coli Chaperone Protein DnaJ

2000 • 119 citations

Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger

1997 • 117 citations

Elucidation of Binding Determinants and Functional Consequences of Ras/Raf-Cysteine-rich Domain Interactions

2000 • 111 citations

Identification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 That Functions in Neuronal Signaling

2000 • 90 citations

A 3D triple-resonance NMR technique for qualitative measurement of carbonyl-Hβ J couplings in isotopically enriched proteins

1992 • 77 citations

Solution Structure of Cysteine-Rich Domain of Protein Kinase Cα1

1995 • 56 citations

Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity

1998 • 56 citations

Domain shuffling as a tool for investigation of protein function: substitution of the cysteine-rich region of Raf kinase and PKC η for that of yeast Pkc1p

2001 • 29 citations