Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Targeting RAS signalling pathways in cancer therapy

2003 • 3,105 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

RHO–GTPases and cancer

2002 • 1,355 citations

RAF/RAS oncogenes and mismatch-repair status

2002 • 1,205 citations

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

2000 • 1,073 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma

2003 • 829 citations

Understanding Ras: ‘it ain’t over ’til it’s over’

2000 • 785 citations

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

2004 • 780 citations

Ras and Rho GTPases

2000 • 779 citations

Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

2001 • 770 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Comparative biology of mouse versus human cells: modelling human cancer in mice

2003 • 540 citations

Genetic Interaction Between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma

2004 • 470 citations

Raf proteins and cancer: B-Raf is identified as a mutational target

2003 • 454 citations

The small GTPase RalA targets filamin to induce filopodia

1999 • 449 citations

The dark side of Ras: regulation of apoptosis

2003 • 430 citations

Distinct requirements for Ras oncogenesis in human versus mouse cells

2002 • 425 citations

Mechanisms of regulating the Raf kinase family

2003 • 397 citations

The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation

2002 • 389 citations

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

2002 • 388 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Phospholipase Cepsilon: a novel Ras effector

2001 • 360 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

V599EB-RAF is an Oncogene in Melanocytes

2004 • 343 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

2004 • 324 citations

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

2002 • 318 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

GAP control: regulating the regulators of small GTPases

2004 • 299 citations

The candidate tumor suppressor gene, RASSF1A , from human chromosome 3p21.3 is involved in kidney tumorigenesis

2001 • 296 citations

Ras Uses the Novel Tumor Suppressor RASSF1 as an Effector to Mediate Apoptosis

2000 • 295 citations

High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma.

2001 • 290 citations

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.

2001 • 286 citations

Analysis of the transcriptional program induced by Raf in epithelial cells

2001 • 255 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Ral-GTPases: approaching their 15 minutes of fame

2003 • 243 citations

Ral GTPases Regulate Exocyst Assembly through Dual Subunit Interactions

2003 • 240 citations

BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer

2003 • 235 citations

In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low‐grade serous tumours

2004 • 233 citations

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

2004 • 219 citations

The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1

2002 • 217 citations

Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma

2003 • 215 citations

Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

1999 • 209 citations

A novel family ofras-binding domains

1996 • 207 citations

Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma.

2001 • 200 citations

RAL GTPases are linchpin modulators of human tumour‐cell proliferation and survival

2003 • 187 citations

RASSF2 Is a Novel K-Ras-specific Effector and Potential Tumor Suppressor

2003 • 182 citations

RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis

2000 • 179 citations

Ras–effector interactions: after one decade

2003 • 177 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Hypermethylation of the CpG island of theRASSF1A gene in ovarian and renal cell carcinomas

2001 • 160 citations

Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways

2001 • 157 citations

Identification of Guanine Nucleotide Exchange Factors (GEFs) for the Rap1 GTPase

2000 • 156 citations

RalA but Not RalB Enhances Polarized Delivery of Membrane Proteins to the Basolateral Surface of Epithelial Cells

2004 • 146 citations

Identification and Characterization of a Novel Protein Interacting with Ral-binding Protein 1, a Putative Effector Protein of Ral

1998 • 143 citations

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

1996 • 142 citations

Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma.

2001 • 138 citations

Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma.

2001 • 135 citations

NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers

2003 • 133 citations

An Eps Homology (EH) Domain Protein That Binds to the Ral-GTPase Target, RalBP1

1997 • 128 citations

An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

2000 • 125 citations

The Pro-apoptotic Ras Effector Nore1 May Serve as a Ras-regulated Tumor Suppressor in the Lung

2003 • 123 citations

The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas

2003 • 118 citations

Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase

2001 • 117 citations

Protein binding and signaling properties of RIN1 suggest a unique effector function

1997 • 114 citations

RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1

2002 • 113 citations

Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-κB

2000 • 105 citations

Regulation of the Forkhead Transcription Factor AFX by Ral-Dependent Phosphorylation of Threonines 447 and 451

2001 • 99 citations

Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases

2004 • 95 citations

The Small GTP-binding Protein Rac Promotes the Dissociation of Gelsolin from Actin Filaments in Neutrophils

1998 • 94 citations

Cell Signaling: Life or Death Decisions of Ras Proteins

2002 • 88 citations

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans

1999 • 87 citations

Ras-Dependent Regulation of c-Jun Phosphorylation Is Mediated by the Ral Guanine Nucleotide Exchange Factor-Ral Pathway

2000 • 78 citations

BRAF and K-ras gene mutations in human pancreatic cancers

2003 • 73 citations

Uncoupling Raf1 from MEK1/2 Impairs Only a Subset of Cellular Responses to Raf Activation

2000 • 72 citations

Ras‐binding domains: predicting function versus folding

1997 • 39 citations

The RASputin effect: Figure 1.

2002 • 27 citations

Essential role of Raf in Ras transformation and deregulation of matrix metalloproteinase expression in ovarian epithelial cells.

2003 • 22 citations