Small Molecular Inhibitor of Transforming Growth Factor-β Protects Against Development of Radiation-Induced Lung Injury

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Principles and Practice of Radiation Oncology

1999 • 1,911 citations

Simple method of estimating severity of pulmonary fibrosis on a numerical scale.

1988 • 1,435 citations

TGF-β and cancer

2005 • 463 citations

Radiation pneumonitis and pulmonary fibrosis in non–small-cell lung cancer: Pulmonary function, prediction, and prevention

2005 • 393 citations

Randomized, Placebo-Controlled Trial of Combined Pentoxifylline and Tocopherol for Regression of Superficial Radiation-Induced Fibrosis

2003 • 343 citations

Radiation pneumonitis and fibrosis: Mechanisms underlying its pathogenesis and implications for future research

2006 • 309 citations

Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

1999 • 296 citations

Current Management for Late Normal Tissue Injury: Radiation-Induced Fibrosis and Necrosis

2007 • 273 citations

Dose-dependent induction of transforming growth factor β (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation

2000 • 267 citations

Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: Interrelationship between the alveolar macrophage and the septal fibroblast

1992 • 216 citations

Principles and Practice of Radiation Oncology

1992 • 202 citations

Responses of Normal Cells to Ionizing Radiation

2007 • 201 citations

Radiation-induced hypoxia may perpetuate late normal tissue injury

2001 • 195 citations

Normal Tissue Tolerance Dose Metrics for Radiation Therapy of Major Organs

2007 • 170 citations

Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (Tbeta R-I and Tbeta R-II) in idiopathic pulmonary fibrosis

2001 • 158 citations

Temporal Onset of Hypoxia and Oxidative Stress After Pulmonary Irradiation

2007 • 139 citations

Molecular Mechanisms of Late Normal Tissue Injury

2007 • 126 citations

Principles and Practice of Radiation Oncology.2nd ed

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Antitransforming growth factor–β antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation

2006 • 124 citations

The physical parameters and molecular events associated with radiation-induced lung toxicity

2000 • 114 citations

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

2007 • 110 citations

Future Strategies for Mitigation and Treatment of Chronic Radiation-Induced Normal Tissue Injury

2007 • 106 citations

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury

2007 • 98 citations

Radiation-induced pulmonary injury: symptomatic versus subclinical endpoints

2000 • 89 citations

SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model

2008 • 78 citations

Soluble TGFβ TYPE II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats

2003 • 66 citations

Genetic Susceptibility To Late Normal Tissue Injury

2007 • 42 citations

Transforming the TGFbeta pathway: convergence of distinct lead generation strategies on a novel kinase pharmacophore for TbetaRI (ALK5).

2004 • 40 citations

Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-β) receptor mediated by adenoviral vector

2004 • 40 citations

DIFFERENTIAL EXPRESSION OF TRANSFORMING GROWTH FACTOR-β TYPE I AND II RECEPTORS BY PULMONARY CELLS IN BLEOMYCIN-INDUCED LUNG INJURY: CORRELATION WITH REPAIR AND FIBROSIS

2002 • 30 citations

Angelica sinensis Down-regulates Hydroxyproline and Tgfb1 and Provides Protection in Mice with Radiation-Induced Pulmonary Fibrosis

2006 • 22 citations

The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology

2008 • 8 citations

TGFβ1 is an important contributing factor in the development of radiation induced fibrosis

2000 • 3 citations

Another simple afterloading applicator

1978 • 1 citations