Multiple Signaling Pathways Involving ATM

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

2000 • 956 citations

The DNA-dependent protein kinase

1999 • 896 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

2000 • 650 citations

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1999 • 570 citations

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

1997 • 489 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

1996 • 385 citations

Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

1997 • 300 citations

ATM-related genes: What do they tell us about functions of the human gene?

1995 • 276 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

1994 • 253 citations

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

1993 • 253 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo.

1996 • 155 citations

DNA damage increases the levels of MDM2 messenger RNA in wtp53 human cells.

1994 • 74 citations

Ataxia-telangiectasia: a multifaceted genetic disorder associated with defective signal transduction

1996 • 67 citations