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2003 • 5,052 citations

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Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine

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Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

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Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

1997 • 445 citations

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

1996 • 414 citations

Mechanisms of TGF-β-mediated apoptosis

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Synthesis and Functional Analyses of Nuclear Clusterin, a Cell Death Protein

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Clusterin/Apolipoprotein J in human aging and cancer

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Links between Tumor Suppressors

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Clusterin is a secreted mammalian chaperone

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Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target

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Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation

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Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

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Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells.

1997 • 264 citations

Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures

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Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

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Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation

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Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.

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Initiation of Apoptosis in Cells Exposed to Medium from the Progeny of Irradiated Cells: A Possible Mechanism for Bystander-Induced Genomic Instability?

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Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts

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Identification of Glycoprotein 330 as an Endocytic Receptor for Apolipoprotein J/Clusterin

1995 • 220 citations

Radiation-Induced Adaptive Response for Protection against Micronucleus Formation and Neoplastic Transformation in C3H 10T1/2 Mouse Embryo Cells

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Interaction of Apolipoprotein J-Amyloid β-Peptide Complex with Low Density Lipoprotein Receptor-related Protein-2/Megalin

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Induction of Cytogenetic Adaptive Response of Somatic and Germ Cellsin Vivoandin Vitroby Low-dose X-irradiation

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Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

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Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands.

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Persistent oxidative stress in chromosomally unstable cells.

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Radiation-induced genomic instability

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Identification and characterization of X-ray-induced proteins in human cells.

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p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding

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Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element

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Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain.

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Radiation-induced effects in unirradiated cells: A review and implications in cancer

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Clusterin (Apolipoprotein J) Protein Levels Are Increased in Hippocampus and in Frontal Cortex in Alzheimer's Disease

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Transforming Growth Factor β (TGFβ)-Induced Nuclear Localization of Apolipoprotein J/Clusterin in Epithelial Cells

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Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

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An overview of the mechanisms of mutagenesis and carcinogenesis

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Clusterin is an extracellular chaperone that specifically interacts with slowly aggregating proteins on their off‐folding pathway

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The bcl, NFκB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-β or TNF-α on activated hepatic stellate cells

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Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells.

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Multiple Receptors Mediate apoJ-Dependent Clearance of Cellular Debris into Nonprofessional Phagocytes

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Bystander-induced Apoptosis and Premature Differentiation in Primary Urothelial Explants after Charged Particle Microbeam Irradiation

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Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect.

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Synergistic chemsensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model.

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Coactivation of AP-1 activity and TGF-β1 gene expression in the stress response of normal skin cells to ionizing radiation

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Clusterin as a biomarker in murine and human intestinal neoplasia

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p53 binds to the TATA-binding protein-TATA complex

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Changes in sternal marrow following roentgen-ray therapy to the spleen in chronic granulocytic leukemia

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A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation

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Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts

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Early Events in the Apoptotic Cascade Initiated in Cells Treated with Medium from the Progeny of Irradiated Cells

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Radio-adaptive response: characterization of a cytogenetic repair induced by low-level ionizing radiation in cultured Chinese hamster cells

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Adaptive Response to DNA-Damaging Agents

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Isolation of Ku70-binding proteins (KUBs)

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Profile of gene expression regulated by induced p53: connection to the TGF‐β family

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Regulation of Clusterin Gene Expression by Transforming Growth Factor β

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Chromosomal instability and its relationship to other end points of genomic instability.

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Repression of IR-Inducible Clusterin Expression by the p53 Tumor Suppressor Protein

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Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation

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Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or alpha-particles

1999 • 88 citations

A role for p53 in the frequency and mechanism of mutation

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TGF-β signalling pathways in early Xenopus development

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Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide

2002 • 85 citations

Critical Target and Dose and Dose-Rate Responses for the Induction of Chromosomal Instability by Ionizing Radiation

1999 • 82 citations

Use of antisense oligonucleotides targeting the antiapoptotic gene, clusterin/testosterone-repressed prostate message 2, to enhance androgen sensitivity and chemosensitivity in prostate cancer

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Fundamental space radiobiology.

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Oxidative stress in cells exposed to low levels of ionizing radiation

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Adaptive response and induced resistance

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Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation

1996 • 73 citations

Dose– and time–response relationships for lethal mutations and chromosomal instability induced by ionizing radiation in an immortalized human keratinocyte cell line

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Transforming growth factor β regulates clusterin gene expression via modulation of transcription factor c‐Fos

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Multiple Involvement of Clusterin in Chicken Ovarian Follicle Development

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Induction of p53 and Bax during TGF-β1 Initiated Apoptosis in Rat Liver Epithelial Cells

1998 • 64 citations

Interaction of Transforming Growth Factor β Receptors with Apolipoprotein J/Clusterin

1996 • 64 citations

Reactive Oxygen Species Act at both TGF-β-Dependent and -Independent Steps during Induction of Apoptosis of Transformed Cells by Normal Cells

1996 • 63 citations

Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic γ-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring

1995 • 58 citations

A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny.

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TGF-β-induced p38 activation is mediated by Rac1-regulated generation of reactive oxygen species in cultured human keratinocytes

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Extracellular Calcium Deprivation in Astrocytes: Regulation of mRNA Expression and Apoptosis

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Induction of an adaptive response to dominant lethality and to chromosome damage of mouse germ cells by low dose radiation

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Plating Efficiency as a Function of Time Postirradiation: Evidence for the Delayed Expression of Lethal Mutations

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Delayed apoptotic responses associated with radiation-induced neoplastic transformation of human hybrid cells.

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Biological effects of low dose radiation

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Analysis of DNA damage recovery processes in the adaptive response to inonizing radiation in human lymphocytes

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TGF-β-Mediated Cell Cycle Arrest of HPV16-Immortalized Human Ectocervical Cells Correlates with Decreased E6/E7 mRNA and Increased p53 and p21WAF-1 Expression

2000 • 36 citations

Apoptotic Cell Debris and Phosphatidylserine-Containing Lipid Vesicles Induce Apolipoprotein J (Clusterin) Gene Expression in Vital Fibroblasts

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Subcellular Distribution, Secretion, and Posttranslational Modifications of Clusterin in Thyrocytes

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Transforming growth factor-β is an endogenous radioresistance factor in the esophageal adenocarcinoma cell line OE-33

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Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.

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TGF beta regulation of cell proliferation.

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Microbeams: A Potent Mix of Physics and Biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation Response

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Genomic instability, bystander effects and radiation risks: implications for development of protection strategies for man and the environment.

2000 • 25 citations

Transforming growth factor-? is an autocrine mitogen for a novel androgen-responsive murine prostatic smooth muscle cell line, PSMC1

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The age-related increase in renal clusterin mRNA is accelerated in obese Zucker rats.

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Adaptive response to ionizing radiation induced by low dose of gamma ray in human hepatoma cell lines

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Clusterin: a protein with multiple functions as a potential ionizing radiation exposure marker

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1999 • 2 citations