An Anti–Transforming Growth Factor β Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

2005 • 2,075 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization

2007 • 1,556 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

Roles of the NKG2D immunoreceptor and its ligands

2003 • 1,297 citations

TGFβ: the molecular Jekyll and Hyde of cancer

2006 • 1,228 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

2003 • 539 citations

Development of TGF-β signalling inhibitors for cancer therapy

2004 • 536 citations

Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer

2006 • 520 citations

Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients

2004 • 518 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 490 citations

Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β

2007 • 438 citations

Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

2003 • 433 citations

Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy

2007 • 425 citations

SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma CellsIn vitroandIn vivo

2004 • 407 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 406 citations

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling

2007 • 397 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 375 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis

2005 • 336 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 326 citations

The role for transforming growth factor-beta (TGF-beta) in human cancer.

1999 • 323 citations

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

2006 • 314 citations

Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.

1989 • 307 citations

RNA Interference Targeting Transforming Growth Factor-β Enhances NKG2D-Mediated Antiglioma Immune Response, Inhibits Glioma Cell Migration and Invasiveness, and Abrogates TumorigenicityIn vivo

2004 • 288 citations

Transforming Growth Factor β Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

2008 • 232 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Dual role for TGF-?1 in apoptosis

2005 • 215 citations

Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype.

1993 • 181 citations

Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer.

1995 • 159 citations

Transforming Growth Factor-β and the Immune Response to Malignant Disease

2007 • 158 citations

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor KinaseIn vivo

2006 • 149 citations

Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-β–Insensitive CD8+ T Cells: Eradication of Autologous Mouse Prostate Cancer

2005 • 147 citations

Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft.

2002 • 144 citations

TGF Beta Inhibition for Cancer Therapy

2006 • 118 citations

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

2007 • 110 citations

Bone Sialoprotein Mediates the Tumor Cell–Targeted Prometastatic Activity of Transforming Growth Factor β in a Mouse Model of Breast Cancer

2006 • 88 citations

Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy.

1999 • 77 citations

Soluble Type II Transforming Growth Factor-β Receptor Inhibits Established Murine Malignant Mesothelioma Tumor Growth by Augmenting Host Antitumor Immunity

2004 • 65 citations

Blockade of transforming growth factor-β signaling in tumor-reactive CD8+ T cells activates the antitumor immune response cycle

2006 • 54 citations

Minimal Effects on Immune Parameters Following Chronic Anti-TGF-β Monoclonal Antibody Administration to Normal Mice

2003 • 53 citations

Reconstitution of Lethally Irradiated Adult Mice with Dominant Negative TGF-β Type II Receptor-Transduced Bone Marrow Leads to Myeloid Expansion and Inflammatory Disease

2002 • 40 citations

Specific and sensitive quantitation of transforming growth factor β3 by sandwich enzyme-linked immunosorbent assay

1995 • 26 citations

Expression of a soluble transforming growth factor-β (TGFβ) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcomain vivo

2003 • 25 citations

Endostatin gene therapy enhances the efficacy of paclitaxel to suppress breast cancers and metastases in mice

2007 • 16 citations

Plasma transforming growth factor beta levels in breast cancer patients.

1998 • 13 citations

VEGF Inhibition for Cancer Therapy

2007 • 3 citations