Transforming Growth Factor β Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Paradoxical roles of the immune system during cancer development

2006 • 2,213 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 • 1,173 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity

2006 • 829 citations

Interleukin-17 promotes angiogenesis and tumor growth

2002 • 795 citations

Transforming growth factor-β in T-cell biology

2002 • 787 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

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Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment

2007 • 410 citations

SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma CellsIn vitroandIn vivo

2004 • 407 citations

IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis

2005 • 404 citations

Plasmacytoid Dendritic Cells Induce CD8+ Regulatory T Cells In Human Ovarian Carcinoma

2005 • 376 citations

TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression

2003 • 352 citations

Interleukin-17 inhibits tumor cell growth by means of a T-cell–dependent mechanism

2002 • 348 citations

The role for transforming growth factor-beta (TGF-beta) in human cancer.

1999 • 323 citations

TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression

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Increased cancer risk after liver transplantation: a population-based study

2001 • 313 citations

Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.

1989 • 307 citations

Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis

2004 • 305 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

2003 • 262 citations

CD8+ IL-17-Producing T Cells Are Important in Effector Functions for the Elicitation of Contact Hypersensitivity Responses

2006 • 243 citations

Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation

1995 • 233 citations

An Anti–Transforming Growth Factor β Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments

2008 • 219 citations

Dual role for TGF-?1 in apoptosis

2005 • 215 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation

2004 • 198 citations

Targeted tumor therapy with the TGF-β2 antisense compound AP 12009

2005 • 188 citations

Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.

2002 • 172 citations

Cancer Incidence in New York State Acquired Immunodeficiency Syndrome Patients

2001 • 151 citations

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor KinaseIn vivo

2006 • 149 citations

Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-β–Insensitive CD8+ T Cells: Eradication of Autologous Mouse Prostate Cancer

2005 • 147 citations

Induction of a distinct CD8 Tnc17 subset by transforming growth factor-β and interleukin-6

2007 • 124 citations

Inoculation of Human Interleukin-17 Gene-Transfected Meth-A Fibrosarcoma Cells Induces T Cell-Dependent Tumor-Specific Immunity in Mice

2001 • 123 citations

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

2007 • 110 citations

Bone Sialoprotein Mediates the Tumor Cell–Targeted Prometastatic Activity of Transforming Growth Factor β in a Mouse Model of Breast Cancer

2006 • 88 citations

Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis

2007 • 76 citations

MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition.

2002 • 67 citations

Soluble Type II Transforming Growth Factor-β Receptor Inhibits Established Murine Malignant Mesothelioma Tumor Growth by Augmenting Host Antitumor Immunity

2004 • 65 citations

Interleukin-17 Receptor-Like Gene Is a Novel Antiapoptotic Gene Highly Expressed in Androgen-Independent Prostate Cancer

2006 • 40 citations

Induction of interleukin-6 in the epidermis of mice in response to tumor-promoting agents

1994 • 13 citations