How T cells 'see' antigen

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Direct observation of ligand recognition by T cells

2002 • 802 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

T cell killing does not require the formation of a stable mature immunological synapse

2004 • 569 citations

Structural Insights into the Evolution of an Antibody Combining Site

1997 • 550 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

2003 • 536 citations

Elaborate interactions between the immune and nervous systems

2004 • 531 citations

Molecular Interactions Mediating T Cell Antigen Recognition

2003 • 495 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

1990 • 410 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

1999 • 400 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

How the immune system works to protect the host from infection: A personal view

2001 • 341 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

How photons start vision.

1996 • 326 citations

A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

2003 • 326 citations

High- and Low-Potency Ligands with Similar Affinities for the TCR

1998 • 322 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

2001 • 314 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

A structural basis for immunodominant human T cell receptor recognition

2003 • 300 citations

The specificity of TCR/pMHC interaction

2002 • 295 citations

Two-step binding mechanism for T-cell receptor recognition of peptide–MHC

2002 • 279 citations

The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

2000 • 254 citations

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

2003 • 253 citations

Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

2003 • 250 citations

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition.

2000 • 249 citations

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

2004 • 241 citations

The Immunological Evolution of Catalysis

1996 • 224 citations

TCRs with high affinity for foreign pMHC show self-reactivity

2002 • 217 citations

Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold

2003 • 210 citations

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands.

1996 • 208 citations

LIGAND RECOGNITION BY T CELL RECEPTORS

1998 • 207 citations

A T Cell Receptor CDR3β Loop Undergoes Conformational Changes of Unprecedented Magnitude Upon Binding to a Peptide/MHC Class I Complex

2002 • 206 citations

The kinetics of protein-protein recognition

1997 • 205 citations

A Functional Hot Spot for Antigen Recognition in a Superagonist TCR/MHC Complex

2000 • 204 citations

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

2005 • 179 citations

Thermodynamics of T cell receptor binding to peptide–MHC: Evidence for a general mechanism of molecular scanning

1999 • 178 citations

Mechanisms Contributing to T Cell Receptor Signaling and Assembly Revealed by the Solution Structure of an Ectodomain Fragment of the CD3ϵγ Heterodimer

2001 • 171 citations

Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3

2004 • 161 citations

Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC

2005 • 154 citations

Control of MHC Restriction by TCR V _α CDR1 and CDR2

1996 • 152 citations

αβ T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization

1997 • 147 citations

Crystal structure of a human CD3-ε/δ dimer in complex with a UCHT1 single-chain antibody fragment

2004 • 143 citations

The T-cell receptor signalosome: a dynamic structure with expanding complexity

2002 • 137 citations

Conversion of a T Cell Antagonist into an Agonist by Repairing a Defect in the TCR/Peptide/MHC Interface

2000 • 135 citations

What do TCR–pMHC crystal structures teach us about MHC restriction and alloreactivity?

2003 • 121 citations

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1998 • 119 citations

Peptide Antagonism and T Cell Receptor Interactions with Peptide-MHC Complexes

1998 • 118 citations

Kinetics and thermodynamics of T cell receptor– autoantigen interactions in murine experimental autoimmune encephalomyelitis

2001 • 105 citations

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4

2001 • 103 citations

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

2002 • 97 citations

Determination of the Relationship Between T Cell Responsiveness and the Number of MHC-Peptide Complexes Using Specific Monoclonal Antibodies

2000 • 93 citations

The interplay between binding energy and catalysis in the evolution of a catalytic antibody

1997 • 90 citations

Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.

1999 • 89 citations

Molecular mechanisms determining the strength of receptor-mediated intermembrane adhesion

1995 • 87 citations

Recognition of multiple peptide cores by a single T cell receptor.

1995 • 84 citations

Cutting Edge: Negative Selection of Immature Thymocytes by a Few Peptide-MHC Complexes: Differential Sensitivity of Immature and Mature T Cells

1999 • 80 citations

Minimal requirements for peptide mediated activation of CD8+ CTL

1994 • 71 citations

Soluble peptide–MHC monomers cause activation of CD8⁺T cells through transfer of the peptide to T cell MHC molecules

2002 • 71 citations

Receptor Proximity, Not Intermolecular Orientation, Is Critical for Triggering T-cell Activation

2001 • 69 citations

Distinct Molecular Mechanisms Account for the Specificity of Two Different T-Cell Receptors

2003 • 52 citations

Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases

1995 • 17 citations