CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

Exact stochastic simulation of coupled chemical reactions

1977 • 10,119 citations

Stochastic Processes in Physics and Chemistry

2007 • 9,372 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Stochastic Processes in Physics and Chemistry

2005 • 2,029 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

An amplified sensitivity arising from covalent modification in biological systems.

1981 • 1,211 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Direct observation of ligand recognition by T cells

2002 • 802 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

2003 • 536 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Quantitative Analysis of the Contribution of TCR/pepMHC Affinity and CD8 to T Cell Activation

2003 • 355 citations

How the immune system works to protect the host from infection: A personal view

2001 • 341 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Dimeric association and segmental variability in the structure of human CD4

1997 • 266 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

2003 • 250 citations

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

2001 • 231 citations

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

2002 • 225 citations

Role of CD4 and CD8 in T Cell Activation and Differentiation

1993 • 172 citations

Dynamics of p56lck Translocation to the T Cell Immunological Synapse following Agonist and Antagonist Stimulation

2002 • 166 citations

Sensitivity amplification in biochemical systems

1982 • 165 citations

Dynamics of Cell Surface Molecules During T Cell Recognition

2003 • 118 citations

Molecular Interactions, T‐Cell Subsets and a Role of the CD4/CD8:p56^lck Complex in Human T‐Cell Activation

1989 • 118 citations

Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation.

1995 • 117 citations

Fluctuations and Quality of Control in Biological Cells: Zero-Order Ultrasensitivity Reinvestigated

2000 • 117 citations

Activated TCRs remain marked for internalization after dissociation from pMHC

2002 • 116 citations

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4

2001 • 103 citations

Cd8− T Cell Transfectants That Express a High Affinity T Cell Receptor Exhibit Enhanced Peptide-Dependent Activation

2001 • 98 citations

CD4 molecules are associated with the antigen receptor complex on activated but not resting T cells.

1988 • 95 citations

p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation.

1992 • 94 citations

Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.

1995 • 94 citations

Detection of Dimers of Dimers of Human Leukocyte Antigen (HLA)–DR on the Surface of Living Cells by Single-Particle Fluorescence Imaging

1998 • 62 citations

Linking molecular and cellular events in T-cell activation and synapse formation

2003 • 55 citations

Direct evidence for native CD4 oligomers in lymphoid and monocytoid cells

1999 • 52 citations

CD4 Dimers Constitute the Functional Component Required for T Cell Activation

2002 • 51 citations

The structure of MHC class II: a role for dimer of dimers

1995 • 49 citations

CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design

1998 • 46 citations

Analysis of the contact sites on the CD4 molecule with class II MHC molecule: co-ligand versus co-receptor function.

1997 • 36 citations

Amino Acid Substitutions in the Putative MHC Class II “Dimer of Dimers” Interface Inhibit CD4+ T Cell Activation

2001 • 23 citations

Interactions of CD4 with MHC class II molecules, T cell receptors and p56^lck

1993 • 16 citations

Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide

2001 • 16 citations

T-cell Activation: The Power of One

2003 • 9 citations