Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

1992 • 3,627 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Backbone dynamics of proteins as studied by nitrogen-15 inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease

1989 • 1,740 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

Determination of three‐dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms Circumventing problems associated with folding

1988 • 546 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

Mapping of spectral density functions using heteronuclear NMR relaxation measurements

1992 • 386 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

Antigenic peptide binding by class I and class II histocompatibility proteins

1994 • 302 citations

Comparison of the Backbone Dynamics of a Folded and an Unfolded SH3 Domain Existing in Equilibrium in Aqueous Buffer

1995 • 299 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Crystal Structure of the β Chain of a T Cell Antigen Receptor

1995 • 267 citations

Surface Structures Involved in Target Recognition by Human Cytotoxic T Lymphocytes

1982 • 238 citations

Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.

1982 • 237 citations

The Human T-Cell Receptor

1984 • 232 citations

The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells

1986 • 225 citations

Automated stereospecific proton NMR assignments and their impact on the precision of protein structure determinations in solution

1989 • 212 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands

1996 • 177 citations

Atomic structure of an alpha beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment derived from a mitogenic antibody

1998 • 174 citations

An Optimized 3D NOESY–HSQC

1996 • 170 citations

Alanine Scanning Mutagenesis of an αβ T Cell Receptor: Mapping the Energy of Antigen Recognition

1998 • 163 citations

An HNCA Pulse Scheme for the Backbone Assignment of 15N,13C,2H-Labeled Proteins: Application to a 37-kDa Trp Repressor-DNA Complex

1994 • 159 citations

Control of MHC Restriction by TCR V _α CDR1 and CDR2

1996 • 152 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Relaxation-Rate Measurements for 15N−1H Groups with Pulsed-Field Gradients and Preservation of Coherence Pathways

1994 • 123 citations

Backbone and methyl dynamics of the regulatory domain of troponin C: anisotropic rotational diffusion and contribution of conformational entropy to calcium affinity

1998 • 118 citations

Identification of a common docking topology with substantial variation among different TCR–peptide–MHC complexes

1998 • 116 citations

Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor.

1994 • 102 citations

The three-dimensional structure of a T-cell antigen receptor Valpha Vbeta heterodimer reveals a novel arrangement of the Vbeta domain

1997 • 99 citations

A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties.

1991 • 97 citations

Possible involvement of the OKT4 molecule in T-cell recognition of class II HLA antigens.

1983 • 71 citations

Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands

1998 • 61 citations

Selection of Antigen-specific T Cells by a Single IEk Peptide Combination

1997 • 52 citations

Analysis of a monoclonal rat antibody directed to the alpha-chain variable region (V alpha 3) of the mouse T cell antigen receptor.

1989 • 51 citations

Measurement of Poorly Resolved Splittings by J Doubling in the Frequency Domain

1994 • 49 citations

The counterreceptor binding site of human CD2 exhibits an extended surface patch with multiple conformations fluctuating with millisecond to microsecond motions

1997 • 44 citations

T-cell antigen receptors with identical variable regions but different diversity and joining region gene segments have distinct specificities but cross-reactive idiotypes.

1987 • 44 citations

Dynamical structure of the antibody combining site as studied by proton-nitrogen-15 shift correlation NMR spectroscopy

1992 • 33 citations

Local Mobility within Villin 14T Probed via Heteronuclear Relaxation Measurements and a Reduced Spectral Density Mapping

1996 • 30 citations

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

1991 • 23 citations

Multiple class I and class II major histocompatibility complex allospecificities are generated with T cell receptor variable (V) domains created by a single Ti beta V gene family.

1985 • 19 citations

Conformational Integrity and Ligand Binding Properties of a Single Chain T-cell Receptor Expressed in Escherichia coli

1997 • 14 citations