Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

F<scp>c</scp>RECEPTOR BIOLOGY

1997 • 1,219 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Controlling Signal Transduction with Synthetic Ligands

1993 • 815 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

The cytosensor microphysiometer: biological applications of silicon technology

1992 • 631 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

INITIATION AND PROCESSING OF SIGNALS FROM THE B CELL ANTIGEN RECEPTOR

1997 • 440 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

X-Ray Crystal Structure of HLA-DR4 (DRA*0101, DRB1*0401) Complexed with a Peptide from Human Collagen II

1997 • 357 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

1998 • 275 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

A New Look at T Cells

1998 • 269 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Crystal Structure of I-Ak in Complex with a Dominant Epitope of Lysozyme

1998 • 245 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

Crystal Structures of Two I-Ad–Peptide Complexes Reveal That High Affinity Can Be Achieved without Large Anchor Residues

1998 • 236 citations

Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

1997 • 235 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

The mouse T cell receptor: Comparison of MHC-restricted receptors on two T cell hybridomas

1983 • 218 citations

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

1997 • 194 citations

Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).

1994 • 185 citations

Altered T Cell Receptor Ligands Trigger a Subset of Early T Cell Signals

1996 • 169 citations

The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence.

1989 • 161 citations

Characterization and crystallization of core streptavidin.

1987 • 146 citations

Variability and repertoire size of T-cell receptor Vα gene segments

1985 • 131 citations

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

1992 • 131 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains.

1994 • 90 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli.

1993 • 58 citations

Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response

1997 • 58 citations

Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface.

1996 • 58 citations

High sensitivity, low affinity—paradox of T-cell receptor recognition

1994 • 54 citations

Superactivation of an immune response triggered by oligomerized T cell epitopes

1997 • 50 citations

Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays.

1992 • 44 citations

T cell activation by preformed, long-lived Ia-peptide complexes. Quantitative aspects.

1988 • 28 citations

THE CYTOSENSOR™-MICROPHYSIOMETER

1994 • 21 citations

How do multichain immune recognition receptors signal? A structural hypothesis

1995 • 14 citations