A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Shape complementarity at protein–protein interfaces

1994 • 1,217 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

A Direct Estimate of the Human αβ T Cell Receptor Diversity

1999 • 893 citations

IMGT, the international ImMunoGeneTics database

2000 • 877 citations

γδ T cells: functional plasticity and heterogeneity

2002 • 773 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Implementation of molecular replacement in AMoRe

2001 • 621 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

EUROPEAN ECONOMIC COMMUNITY

1983 • 322 citations

The specificity of TCR/pMHC interaction

2002 • 295 citations

Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

1994 • 289 citations

Two-step binding mechanism for T-cell receptor recognition of peptide–MHC

2002 • 279 citations

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease.

1994 • 275 citations

T Cell Receptor–MHC Interactions up Close

2001 • 252 citations

Structure of a human γδ T-cell antigen receptor

2001 • 243 citations

Qualitative and Quantitative Differences in T Cell Receptor Binding of Agonist and Antagonist Ligands

1999 • 226 citations

IMGT, the international ImMunoGeneTics database

2001 • 220 citations

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

2000 • 208 citations

A T Cell Receptor CDR3β Loop Undergoes Conformational Changes of Unprecedented Magnitude Upon Binding to a Peptide/MHC Class I Complex

2002 • 206 citations

T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen.

1995 • 189 citations

Atomic structure of an alpha beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment derived from a mitogenic antibody

1998 • 174 citations

Mechanisms Contributing to T Cell Receptor Signaling and Assembly Revealed by the Solution Structure of an Ectodomain Fragment of the CD3ϵγ Heterodimer

2001 • 171 citations

Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivity

1997 • 166 citations

Control of MHC Restriction by TCR V _α CDR1 and CDR2

1996 • 152 citations

Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific

1998 • 150 citations

The Shaping of the T Cell Repertoire

2001 • 134 citations

Changing Patterns of Dominant TCR Usage with Maturation of an EBV-Specific Cytotoxic T Cell Response

2000 • 117 citations

Identification of a common docking topology with substantial variation among different TCR–peptide–MHC complexes

1998 • 116 citations

Shapes of MHC Restriction

1999 • 100 citations

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

2002 • 97 citations

The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization

2002 • 72 citations

The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance

2002 • 72 citations

T cell selection during the evolution of CD8+ T cell memoryin vivo

1998 • 70 citations

One of the CD3ε Subunits within a T Cell Receptor Complex Lies in Close Proximity to the Cβ FG Loop

1998 • 68 citations

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

2002 • 62 citations

The immunology of Epstein–Barr virus infection

2001 • 62 citations

Canonical structures for the hypervariable regions of T cell αβ receptors

2000 • 59 citations

Human leukocyte antigen phenotype imposes complex constraints on the antigen‐specific cytotoxic T lymphocyte repertoire

1997 • 39 citations

Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8⁺T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure

2001 • 37 citations

Selection of T cell receptor variable gene‐encoded amino acids on the third binding site loop: a factor influencing variable chain selection in a T cell response

1995 • 16 citations

Amino acids specifying MHC class preference in TCR V alpha 2 regions.

1999 • 16 citations

Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition

1997 • 14 citations

Crystal structure of a T cell receptor Vα11 (AV11S5) domain: new canonical forms for the first and second complementarity determining regions

2001 • 14 citations

Amino Acids Specifying MHC Class Preference in TCR Vα2 Regions

1999 • 12 citations

Positive Selection of Vβ2⁺ CD8⁺ T cells

1992 • 10 citations

Characterization of the epitope on murine T-cell receptor (TCR) alpha proteins recognized by H28-710 monoclonal antibody.

1999 • 8 citations