Costimulation and endogenous MHC ligands contribute to T cell recognition

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Co-stimulation in T cell responses

1997 • 430 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

1998 • 275 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Regulation of leukocyte integrin function: Affinity vs. avidity

1996 • 244 citations

Intercellular Communication and Cell-Cell Adhesio n

1992 • 230 citations

Cutting Edge: The Dendritic Cell Cytoskeleton Is Critical for the Formation of the Immunological Synapse

2001 • 213 citations

Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.

1991 • 213 citations

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

1996 • 210 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

1997 • 194 citations

Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).

1994 • 185 citations

Characterization and Quantitation of Peptide–MHC Complexes Produced from Hen Egg Lysozyme Using a Monoclonal Antibody

1997 • 169 citations

Alanine Scanning Mutagenesis of an αβ T Cell Receptor: Mapping the Energy of Antigen Recognition

1998 • 163 citations

The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond

1996 • 148 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

A Kinetic Threshold between Negative and Positive Selection Based on the Longevity of the T Cell Receptor–Ligand Complex

1999 • 122 citations

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte–antigen-presenting cell interface

2000 • 117 citations

Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins.

1996 • 105 citations

The minimal number of antigen‐major histocompatibility complex class II complexes required for activation of naive and primed T cells

1997 • 100 citations

A Murine T Cell Receptor Gene Complex: Isolation, Structure and Rearrangement

1984 • 89 citations

Induction of MHC-restricted specificity and tolerance in the thymus

1986 • 82 citations

Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP.

1998 • 43 citations

Disruption of the CD4–major histocompatibility complex class II interaction blocks the development of CD4⁺T cellsin vivo

1998 • 38 citations

A T Cell Receptor–specific Blockade of Positive Selection

1999 • 34 citations

Cutting Edge: Nuclear Factor of Activated T Cells and AP-1 Are Insufficient for IL-2 Promoter Activation: Requirement for CD28 Up-Regulation of RE/AP

1998 • 31 citations

Signalling and adhesive properties of the integrin leucocyte function-associated antigen I (LFA-I)

1997 • 16 citations

CD28 co-receptor signal transduction in T-cell activation

1997 • 16 citations

Recognition of the Major Histocompatibility Complex Restriction Element Modulates CD8+ T Cell Specificity and Compensates for Loss of T Cell Receptor Contacts with the Specific Peptide

1999 • 14 citations

Selection and Function of CD4+ T Lymphocytes in Transgenic Mice Expressing Mutant MHC Class II Molecules Deficient in Their Interaction with CD4

1998 • 14 citations

Alterations in CD4-Binding Regions of the MHC Class II Molecule I-Ek Do Not Impede CD4+ T Cell Development

1999 • 13 citations

Naturally Occurring Low Affinity Peptide/MHC Class I Ligands Can Mediate Negative Selection and T Cell Activation

1998 • 13 citations

Coreceptor-Independent T Cell Activation in Mice Expressing MHC Class II Molecules Mutated in the CD4 Binding Domain

1998 • 5 citations