Thermodynamics of T cell receptor binding to peptide–MHC: Evidence for a general mechanism of molecular scanning

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Coupling of Local Folding to Site-Specific Binding of Proteins to DNA

1994 • 1,382 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling

1996 • 948 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Structural Insights into the Evolution of an Antibody Combining Site

1997 • 550 citations

Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition

1992 • 519 citations

CDR3 length in antigen-specific immune receptors.

1994 • 503 citations

Bound water molecules and conformational stabilization help mediate an antigen-antibody association.

1994 • 471 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.

1993 • 437 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Role of the hydrophobic effect in stability of site-specific protein-DNA complexes

1989 • 380 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

The price of lost freedom: entropy of bimolecular complex formation

1989 • 323 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

1990 • 224 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

Major antigen-induced domain rearrangements in an antibody

1993 • 206 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Structural energetics of peptide recognition: Angiotensin II/antibody binding

1993 • 167 citations

Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity.

1993 • 149 citations

Role of hydrophobicity in the binding of coenzymes

1978 • 133 citations

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.

1993 • 97 citations

Detailed Analysis of the Free and Bound Conformations of an Antibody

1993 • 95 citations

The DNA Binding Arm of λ Repressor: Critical Contacts from a Flexible Region

1991 • 88 citations

Configurational effects in antibody–antigen interactions studied by microcalorimetry

1995 • 80 citations

Isothermal Titration Calorimetric Study of the Association of Hen Egg Lysozyme and the Anti-Lysozyme Antibody HyHEL-5

1994 • 79 citations

Positive and Negative Thymocyte Selection

1998 • 72 citations

Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli.

1993 • 58 citations

Role of Salt Bridge Formation in Antigen-Antibody Interaction

1996 • 56 citations

Thermodynamic Study of the pH-Dependent Interaction of Chromogranin A with an Intraluminal Loop Peptide of the Inositol 1,4,5-Trisphosphate Receptor

1995 • 43 citations

Hydrogen Bonding and Solvent Structure in an Antigen−Antibody Interface. Crystal Structures and Thermodynamic Characterization of Three Fv Mutants Complexed with Lysozyme^,

1996 • 43 citations

T-cell receptor peptide-MHC interactions: biological lessons from structural studies

1998 • 21 citations

The DNA binding arm of lambda repressor: critical contacts from a flexible region

1991 • 21 citations