The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

The Immunological Synapse

2001 • 987 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

T CELL MEMORY

1998 • 863 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

T cell antigen receptor signal transduction

1997 • 390 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation

1997 • 338 citations

Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chain

1992 • 333 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

DIMERIZATION AS A REGULATORY MECHANISM IN SIGNAL TRANSDUCTION

1998 • 321 citations

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

1991 • 307 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Antigen presentation by supported planar membranes containing affinity-purified I-Ad.

1984 • 281 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens.

1986 • 250 citations

Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

1997 • 235 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Qualitative and Quantitative Differences in T Cell Receptor Binding of Agonist and Antagonist Ligands

1999 • 226 citations

Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin

1982 • 224 citations

Adaptors and Molecular Scaffolds in Immune Cell Signaling

1999 • 222 citations

Tolerance of T-cell clones is associated with membrane antigen changes

1983 • 187 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

Receptor clustering on a cell surface. I. theory of receptor cross-linking by ligands bearing two chemically identical functional groups

1980 • 150 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

Multivalent structure of an αβT cell receptor

1999 • 140 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1998 • 119 citations

Serial TCR Engagement and Down-Modulation by Peptide:MHC Molecule Ligands: Relationship to the Quality of Individual TCR Signaling Events

1999 • 117 citations

Potent T Cell Activation with Dimeric Peptide–Major Histocompatibility Complex Class II Ligand: The Role of CD4 Coreceptor

1998 • 106 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

Empty and Peptide-Loaded Class II Major Histocompatibility Complex Proteins Produced by Expression inEscherichia coliand Foldingin Vitro

1999 • 97 citations

Antigen-Specific Signaling by a Soluble, Dimeric Peptide/Major Histocompatibility Complex Class II/Fc Chimera Leading to T Helper Cell Type 2 Differentiation

1999 • 63 citations

Activation requirements for normal T cells: accessory cell-dependent and -independent stimulation by anti-receptor antibodies.

1986 • 46 citations

Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays.

1992 • 44 citations

T cell activation by preformed, long-lived Ia-peptide complexes. Quantitative aspects.

1988 • 28 citations

Quantitative analysis of the T cell response to antigen and planar membranes containing purified Ia molecules.

1987 • 19 citations

Seeing double

1993 • 16 citations

Purified HLA class II peptide complexes can induce adherence and activation of peptide-specific human T cell clones.

1992 • 9 citations