Clinical multidrug resistance in cancer: A multifactorial problem

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study.

1992 • 734 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

The drug resistance-related protein LRP is the human major vault protein

1995 • 621 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck.

1992 • 617 citations

p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies

1994 • 585 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

1995 • 501 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

1991 • 447 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Expression of P-Glycoprotein in High-Grade Osteosarcomas in Relation to Clinical Outcome

1995 • 401 citations

Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-hour 5-FU infusion and cisplatin

1985 • 392 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 372 citations

MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia

1991 • 372 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells.

1978 • 268 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.

1991 • 261 citations

EPOCH chemotherapy: toxicity and efficacy in relapsed and refractory non-Hodgkin's lymphoma.

1993 • 247 citations

Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis

1995 • 244 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 231 citations

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

1991 • 229 citations

Drug Resistance-Associated Marker Lrp for Prediction of Response to Chemotherapy and Prognoses in Advanced Ovarian Carcinoma

1995 • 225 citations

Relationship of cellular glutathione to the cytotoxicity and resistance of seven platinum compounds.

1992 • 215 citations

Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution.

1995 • 208 citations

Clinical Relevance of Immunohistochemical Detection of Multidrug Resistance P-Glycoprotein in Breast Carcinoma

1991 • 208 citations

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein

1995 • 206 citations

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer.

1995 • 203 citations

DNA Topoisomerases as Anticancer Drug Targets

1990 • 195 citations

Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance.

1994 • 186 citations

Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia

1995 • 182 citations

Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.

1987 • 180 citations

P‐glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

1991 • 177 citations

Spheroids in Cancer Research

1984 • 176 citations

Expression of the multidrug resistance-associated protein (MRP) gene in human cancers.

1995 • 174 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 172 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines

1993 • 149 citations

Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.

1990 • 148 citations

Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.

1992 • 135 citations

Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.

1989 • 132 citations

Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations of apoptosis and drug resistance.

1995 • 121 citations

Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo.

1972 • 115 citations

Elevated DNA repair capacity is associated with intrinsic resistance of lung cancer to chemotherapy.

1995 • 115 citations

Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

1994 • 113 citations

Main drug-metabolizing enzyme systems in human breast tumors and peritumoral tissues.

1993 • 110 citations

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein

1991 • 106 citations

Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias.

1994 • 104 citations

Organ-Specific Modulation of Steady-State mdr Gene Expression and Drug Resistance in Murine Colon Cancer Cells

1994 • 103 citations

Genetic polymorphisms in xenobiotic metabolism

1994 • 102 citations

High levels of constitutive WAF1/Cip1 protein are associated with chemoresistance in acute myelogenous leukemia.

1995 • 97 citations

Effect of verapamil and other agents on the distribution of anthracyclines and on reversal of drug resistance.

1987 • 96 citations

Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase.

1994 • 96 citations

Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells.

1992 • 94 citations

Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target.

1986 • 93 citations

Expression of resistance factors (P-glycoprotein, glutathione S-transferase-π, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas

1993 • 93 citations

Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.

1995 • 92 citations

Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases.

1992 • 89 citations

Assessment of P-glycoprotein, glutathione-based detoxifying enzymes and O6-alkylguanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors.

1991 • 88 citations

Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation

1995 • 85 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia.

1995 • 79 citations

Overexpression of P-glycoprotein and glutathione S-transferase-π in resistant non-small cell lung carcinomas of smokers

1991 • 78 citations

Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer.

1995 • 76 citations

Drug resistance: genotype versus phenotype--thirty-second G. H. A. Clowes Memorial Award Lecture.

1994 • 75 citations

Normal p53 status and function despite the development of drug resistance in human breast cancer cells.

1995 • 72 citations

Wild Type p53 Stimulates Expression from the Human Multidrug Resistance Promoter in a p53-negative Cell Line

1995 • 70 citations

Glutathione S-transferase pi in colorectal tumors is predictive for overall survival.

1995 • 69 citations

P-glycoprotein in Adult Hematologic Malignancies

1995 • 67 citations

Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha. Delineation of a carboxy-terminal epitope with peptide antibodies.

1995 • 64 citations

Resistance‐associated factors in human small‐cell lung‐carcinoma GLC₄ sub‐lines with increasing adriamycin resistance

1995 • 63 citations

Acquired resistance to cisplatin and doxorubicin in a small cell lung cancer cell line is correlated to elevated expression of glutathione-linked detoxification enzymes

1994 • 62 citations

Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells

1993 • 61 citations

Infusional cyclophosphamide, doxorubicin, and etoposide in relapsed and resistant non-Hodgkin's lymphoma: evidence for a schedule-dependent effect favoring infusional administration of chemotherapy.

1993 • 59 citations

P-glycoprotein in Adult Solid Tumors: Expression and Prognostic Significance

1995 • 59 citations

Effect of duration of exposure to verapamil on vincristine activity against multidrug-resistant human leukemic cell lines.

1989 • 59 citations

Genetic Differences in Drug Disposition

1994 • 58 citations

Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants.

1994 • 56 citations

Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia

1992 • 52 citations

Expression of MDR1 and GST-π in human soft tissue sarcomas: Relation to drug resistance and biological aggressiveness

1992 • 52 citations

Glutathione S-transferase activity and isoenzyme composition in benign ovarian tumours, untreated malignant ovarian tumours, and malignant ovarian tumours after platinum/cyclophosphamide chemotherapy

1992 • 50 citations

Cell-cycle-dependent phosphorylation and activity of Chinese-hamster ovary topoisomerase II

1993 • 48 citations

Mechanistic studies of amsacrine-resistant derivatives of DNA topoisomerase II. Implications in resistance to multiple antitumor drugs targeting the enzyme.

1994 • 47 citations

Intratumor variability in prognostic indicators may be the cause of conflicting estimates of patient survival and response to therapy.

1994 • 42 citations

Relationship of inherent resistance to doxorubicin, proliferative activity and expression of P-glycoprotein 170, and glutathione S-transf erase-π in human lung tumors

1992 • 42 citations

Quantitative and qualitative aspects of topoisomerase I and II alpha and beta in untreated and platinum/cyclophosphamide treated malignant ovarian tumors.

1994 • 41 citations

p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia

1993 • 40 citations

Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer

1993 • 39 citations

Parallel assessment of glutathione‐based detoxifying enzymes, O⁶‐alkylguanine‐dna alkyltransferase and P‐glycoprotein as indicators of drug resistance in tumor and normal lung of patients with lung cancer

1994 • 39 citations

High mdrl- and mrp-, but low topoisomerase IIα-gene expression in B-cell chronic lymphocytic leukaemias

1994 • 39 citations

O6-alkylguanine-DNA-alkyltransferase activity and nitrosourea sensitivity in human cancer cell lines

1992 • 36 citations

P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo

1995 • 35 citations

Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts.

1994 • 34 citations

Functions of the p53 Protein in Growth Regulation and Tumor Suppression

1994 • 32 citations

Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle.

1994 • 30 citations

The influence of tumor cell density on cellular accumulation of doxorubicin or cisplatin in vitro

1991 • 29 citations

Expression of the multiple drug resistance gene in human renal cell carcinoma depends on tumor histology, grade, and stage.

1995 • 28 citations

Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.

1993 • 27 citations

Modulation of Glutathione and Related Enzymes in Reversal of Resistance to Anticancer Drugs

1995 • 26 citations

Comparative chemosensitivity of exponential- versus plateau-phase cells in both in vitro model systems.

1976 • 23 citations

Topoisomerase II alpha expression in acute myeloid leukaemia and its relationship to clinical outcome.

1994 • 23 citations

Cytostatic drug resistance: parallel assessment of glutathione‐based detoxifying enzymes, O6‐alkylguanine‐DNA‐alkyltransferase and P‐glycoprotein in adult patients with leukaemia

1993 • 22 citations

Expression of drug resistance-associated mdr-1, GST π, and topoisomerase II genes during cell cycle traverse

1995 • 22 citations

Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.

1994 • 21 citations

Multidrug resistance in breast cancer: Mechanisms, strategies

1995 • 20 citations

Regrowth resistance in cancer: why has it been largely ignored?

1995 • 13 citations

Expression of topoisomerase II, bcl-2, and p53 in three human brain tumor cell lines and their possible relationship to intrinsic resistance to etoposide.

1995 • 11 citations

Effect of duration of exposure to S9788, cyclosporin A or verapamil on sensitivity of multidrug resistant cells to vincristine or doxorubicin.

1993 • 7 citations

Upregulation of O⁶-alkylguanine-DNA-alkyltransferase expression and the presence of double minute chromosomes in alkylating agent selected Chinese hamster cells

1992 • 5 citations