p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Gain of function mutations in p53

1993 • 876 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

1996 • 382 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Multidrug Resistance in Cancer

1989 • 258 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

1989 • 233 citations

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

1987 • 196 citations

Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein

1995 • 191 citations

Inhibition of viral and cellular promoters by human wild-type p53

1992 • 178 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation.

1989 • 162 citations

Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

1993 • 151 citations

The molecular epidemiology of P53 gene mutations in human breast cancer

1997 • 142 citations

Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites.

1995 • 132 citations

The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.

1993 • 120 citations

A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

1993 • 107 citations

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.

1996 • 103 citations

p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat

1995 • 97 citations

Multidrug resistance of cancer cells

1996 • 89 citations

Transcriptional regulation of the dihydrofolate reductase gene

1996 • 89 citations

Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells.

1996 • 79 citations

P-glycoprotein expression during tumor progression in the rat liver.

1992 • 77 citations

The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited

1995 • 66 citations

Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes.

1993 • 59 citations

A method for the synchronization of cultured cells with aphidicolin: Application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase

1989 • 56 citations

Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids.

1995 • 36 citations

Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver

1994 • 31 citations

Expression of a Drug Resistance Gene in Human Neuroblastoma Cell Lines: Modulation by Retinoic Acid-Induced Differentiation

1989 • 27 citations

Bromocriptine Transcriptionally Activates the Multidrug Resistance Gene (pgp2/mdr1b) by a Novel Pathway

1997 • 24 citations

The rat genome contains a p53 pseudogene: detection of a processed pseudogene using PCR.

1992 • 24 citations