The role of the MDR protein in altered drug translocation across tumor cell membranes

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Intracellular pH.

1981 • 2,440 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

[64] The measurement of membrane potential and ΔpH in cells, organelles, and vesicles

1979 • 807 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

BACTERIAL PERIPLASMIC TRANSPORT SYSTEMS: STRUCTURE, MECHANISM, AND EVOLUTION

1986 • 690 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs

1993 • 366 citations

Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient

1986 • 363 citations

The cell biology of multiple drug resistance

1987 • 340 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Mechanisms of active transport in isolated bacterial membrane vesicles. 28. Membrane potential and active transport in membrane vesicles from Escherichia coli

1975 • 319 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

1986 • 275 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients

1990 • 239 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

Properties and structural basis of simple diffusion pathways in the erythrocyte membrane

2005 • 195 citations

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

1995 • 191 citations

Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential

1985 • 186 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

Reconstitution of Drug Transport by Purified P-glycoprotein

1995 • 172 citations

Transport and binding of daunorubicin, adriamycin, and rubidazone in ehrlich ascites tumour cells

1977 • 169 citations

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1992 • 157 citations

Current-voltage relationships for the plasma membrane and its principal electrogenic pump inNeurospora crassa: I. Steady-state conditions

1978 • 156 citations

Pharmacology, 3rd edn

1982 • 156 citations

Optical methods in cell physiology

1987 • 153 citations

Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines

1993 • 149 citations

An estimation of the light-induced electrochemical potential difference of protons across the membrane of Halobacterium halobium

1976 • 144 citations

Characterization of multidrug resistance by fluorescent dyes.

1991 • 138 citations

Functional expression of P-glycoproteins in secretory vesicles.

1994 • 134 citations

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein

1993 • 131 citations

Genetic basis of multidrug resistance of tumor cells

1990 • 124 citations

Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in ehrlich ascites tumour cells

1978 • 121 citations

Increased Cytosolic pH in Multidrug-Resistant Human Lung Tumor Cells: Effect of Verapamil

1989 • 120 citations

Purified lac permease and cytochrome o oxidase are functional as monomers.

1987 • 117 citations

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

1992 • 114 citations

Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.

1990 • 108 citations

Potential-sensitive molecular probes in membranes of bioenergetic relevance

1990 • 107 citations

Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye.

1990 • 104 citations

Kinetics of daunorubicin transport by P‐glycoprotein of intact cancer cells

1992 • 104 citations

Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

1994 • 103 citations

Multidrug resistance in human cancer

1992 • 103 citations

Cellular transport of anthracyclines by passive diffusion

1985 • 102 citations

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug resistant cells expressing different levels of P-glycoprotein

1992 • 102 citations

Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.

1989 • 97 citations

Comparison of the membrane transport of anthracycline derivatives in drug‐resistant and drug‐sensitive K562 cells

1991 • 97 citations

Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles.

1987 • 96 citations

Markedly altered membrane transport and intracellular binding of vincristine in multidrug‐resistant Chinese hamster cells selected for resistance to vinca alkaloids

1986 • 94 citations

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site

1993 • 91 citations

The Electrochemical Proton Gradient of Saccharomyces

1982 • 89 citations

Optical methods in cell physiology

1986 • 89 citations

Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.

1994 • 87 citations

Gating and conductance in an outward-rectifying K+ channel from the plasma membrane of Saccharomyces cerevisiae

1993 • 87 citations

Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil

1987 • 79 citations

Molecular biology of active transport: from membrane to molecule to mechanism.

1987 • 79 citations

Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene.

1994 • 79 citations

Periplasmic binding protein-dependent transport systems: the membrane-associated components

1990 • 77 citations

Relevance of the chemical charge of rhodamine dyes to multiple drug resistance

1989 • 77 citations

Doxorubicin resistance in P388 leukemia—evidence for reduced drug influx

1989 • 72 citations

Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells

1990 • 72 citations

Selection for MDR1/P-glycoprotein enhances swelling-activated K+ and Cl- currents in NIH/3T3 cells

1994 • 69 citations

Low External pH and Osmotic Shock Increase the Expression of Human MDR Protein

1994 • 66 citations

Enhanced efflux of [3H]vinblastine from Chinese hamster ovary cells transfected with a full-length complementary DNA clone for the mdr1 gene.

1989 • 64 citations

A model for computer simulation of P-glycoprotein and transmembrane ΔpH-mediated anthracycline transport in multidrug-resistant tumor cells

1990 • 57 citations

Membrane potential differences between adriamycin-sensitive and -resistant cells as measured by flow cytometry

1989 • 57 citations

Up-regulation of a mutant form of p53 by doxorubicin in human squamous carcinoma cells.

1994 • 55 citations

The role of drug-lipid interactions in the biological activity of modulators of multi-drug resistance

1993 • 53 citations

Uptake of safranine and other lipophilic cations into model membrane systems in response to a membrane potential

1985 • 52 citations

Functional consequences of heterologous expression of the cystic fibrosis transmembrane conductance regulator in fibroblasts.

1993 • 51 citations

Functional studies of P-glycoprotein in inside-out plasma membrane vesicles derived from murine erythroleukemia cells overexpressing MDR 3. Properties and kinetics of the interaction of vinblastine with P-glycoprotein and evidence for its active mediated transport.

1994 • 49 citations

Correction of altered plasma membrane potentials

1988 • 47 citations

P-glycoprotein-associated Cl- currents are activated by cell swelling but do not contribute to cell volume regulation.

1994 • 45 citations

A comparison of membrane properties and composition between cell lines selected and transfected for multi-drug resistance

1992 • 45 citations

Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.

1990 • 44 citations

The gene encoding vacuolar H+-ATPase subunit C is overexpressed in multidrug resistant HL60 cells

1992 • 44 citations

Uptake of dibucaine into large unilamellar vesicles in response to a membrane potential.

1985 • 41 citations

Transfection of mu MDR 1 Inhibits Na+-Independent Cl-/-HCO3 Exchange in Chinese Hamster Ovary Cells

1994 • 40 citations

Kinetics and pH-dependence of glycine-proton symport in Saccharomyces cerevisiae

1984 • 40 citations

Novel Cl--Dependent Intracellular pH Regulation in Murine MDR 1 Transfectants and Potential Implications

1994 • 39 citations

Influence of ion gradients on the transbilayer distribution of dibucaine in large unilamellar vesicles

1988 • 38 citations

Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient

1990 • 36 citations

The inability of the mouse mdr2 gene to confer multidrug resistance is linked to reduced drug binding to the protein.

1994 • 34 citations

Diversity of multidrug resistance in mammalian cells.

1994 • 30 citations

Depolymerization of microtubules alters membrane potential and affects the motional freedom of membrane proteins

1986 • 29 citations

Kinetics of Transport of Dialkyloxacarbocyanines in Multidrug-Resistant Cell Lines Overexpressing P-glycoprotein: Interrelationship of Dye Alkyl Chain Length, Cellular Flux, and Drug Resistance

1995 • 28 citations

Analysis of Drug Transport Kinetics in Multidrug-Resistant Cells Using a Novel Coumarin-Vinblastine Compound

1994 • 24 citations

Kinetic parameters for the uptake of anthracycline by drug‐resistant and drug‐sensitive K562 cells

1992 • 23 citations

Intrinsic drug resistance in a human medullary thyroid carcinoma cell line: association with overexpression of mdrl gene and low proliferation fraction.

1991 • 22 citations

Drugs Transported by P-Glycoprotein Inhibit a 40pS Outwardly Rectifying Chloride Channel

1994 • 20 citations

Reduced influx is a factor in accounting for reduced vincristine accumulation in certain verapamil‐hypersensitive multidrug‐resistant CHO cell lines

1993 • 19 citations

Comparison of adriamycin and derivatives uptake into large unilamellar lipid vesicles in response to a membrane potential

1993 • 16 citations

Components of intrinsic drug resistance in the rat hepatoma

1992 • 10 citations

Uptake of the noncytotoxic transport probe procainamide in the Chinese hamster ovary model of multidrug resistance.

1992 • 9 citations