Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
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References (210)
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Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
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BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex
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Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
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Neurotrophins regulate dendritic growth in developing visual cortex
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Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
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Gene transfer and molecular cloning of the rat nerve growth factor receptor
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CREB: A Major Mediator of Neuronal Neurotrophin Responses
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Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
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A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway
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p75 and Trk: A two-receptor system
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Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
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Functional Interactions of Neurotrophins and Neurotrophin Receptors
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Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
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Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
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BDNF regulates eating behavior and locomotor activity in mice
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trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.
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Induction of Apoptosis by the Low-Affinity NGF Receptor
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Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
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Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
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Induction of cell death by endogenous nerve growth factor through its p75 receptor
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Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein
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Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
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Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
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Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor
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Opposing Roles for Endogenous BDNF and NT-3 in Regulating Cortical Dendritic Growth
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Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons
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Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF
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Synapsins as mediators of BDNF-enhanced neurotransmitter release
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REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE
1998 • 544 citations
Neurotrophin-evoked rapid excitation through TrkB receptors
1999 • 540 citations
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
1994 • 538 citations
A structural superfamily of growth factors containing a cystine knot motif
1993 • 529 citations
Intraventricular Administration of BDNF Increases the Number of Newly Generated Neurons in the Adult Olfactory Bulb
1998 • 528 citations
Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth
1999 • 516 citations
Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity
1996 • 503 citations
New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor
1991 • 500 citations
The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death
1998 • 500 citations
Brain-derived neurotrophic factor prevents neuronal death in vivo
1988 • 490 citations
Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival
1998 • 476 citations
The role of neurotrophins in the developing nervous system
1994 • 472 citations
Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling
1996 • 472 citations
Learning Deficit in BDNF Mutant Mice
1997 • 470 citations
Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice
1999 • 463 citations
An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death
2000 • 461 citations
BDNF Has Opposite Effects on the Quantal Amplitude of Pyramidal Neuron and Interneuron Excitatory Synapses
1998 • 460 citations
Nerve growth factor mediates signal transduction through trk homodimer receptors
1992 • 458 citations
Signal transduction underlying growth cone guidance by diffusible factors
1999 • 457 citations
The nerve growth factor: its mode of action on sensory and sympathetic nerve cells.
1966 • 456 citations
CREB Couples Neurotrophin Signals to Survival Messages
2000 • 455 citations
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
1999 • 452 citations
In Vitro Experiments on the Effects of Mouse Sarcomas 180 and 37 on the Spinal and Sympathetic Ganglia of the Chick Embryo
1997 • 449 citations
Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes
1996 • 434 citations
Abnormal Cerebellar Development and Foliation in BDNF−/− Mice Reveals a Role for Neurotrophins in CNS Patterning
1997 • 432 citations
Body and Brain: A Trophic Theory of Neural Connections
1992 • 426 citations
Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains
1999 • 408 citations
Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells
1994 • 397 citations
Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
1999 • 396 citations
Involvement of a novel Tnf receptor homologue in hair follicle induction
1999 • 385 citations
Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependyma
1999 • 384 citations
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
1995 • 381 citations
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF
1995 • 381 citations
The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development.
1994 • 371 citations
Development of Sensory Neurons in the Absence of NGF/TrkA Signaling In Vivo
2000 • 363 citations
p75-Deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
1993 • 359 citations
Neurotrophin Signaling via Trks and p75
1999 • 356 citations
Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.
1996 • 350 citations
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
1999 • 343 citations
BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain
2000 • 341 citations
The nerve growth factor family
1990 • 326 citations
Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation
1998 • 322 citations
Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway
1995 • 319 citations
Neurotrophin regulation of synaptic transmission
1999 • 315 citations
High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.
1994 • 313 citations
Blockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns
1997 • 309 citations
NMR structure of the death domain of the p75 neurotrophin receptor
1997 • 301 citations
trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues
1993 • 293 citations
Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.
1993 • 292 citations
Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.
1994 • 291 citations
NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis
2000 • 287 citations
Developmental and mature expression of full-length and truncated TrkB, receptors in the rat forebrain
1996 • 281 citations
Synaptic Innervation Density Is Regulated by Neuron-Derived BDNF
1997 • 280 citations
Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus
1998 • 278 citations
p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF
1994 • 278 citations
Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth
2000 • 278 citations
Cortical Degeneration in the Absence of Neurotrophin Signaling
2000 • 277 citations
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
1997 • 276 citations
Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development
1995 • 270 citations
Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity
1997 • 268 citations
BDNF Mediates the Effects of Testosterone on the Survival of New Neurons in an Adult Brain
1999 • 267 citations
TrkB and TrkC Signaling Are Required for Maturation and Synaptogenesis of Hippocampal Connections
1998 • 266 citations
t Brain-Derived Neurotrophic Factor Overexpression Induces Precocious Critical Period in Mouse Visual Cortex
1999 • 264 citations
Nerve growth factor (NGF) prevents the shift in ocular dominance distribution of visual cortical neurons in monocularly deprived rats
1992 • 255 citations
Neurotrophins Induce Sphingomyelin Hydrolysis
1995 • 245 citations
Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation
1999 • 242 citations
Association of the p75 Neurotrophin Receptor with TRAF6
1999 • 237 citations
The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA
1999 • 231 citations
TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons.
1996 • 231 citations
Survival of Cholinergic Forebrain Neurons in Developing p75 NGFR -Deficient Mice
1996 • 227 citations
Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse
1990 • 227 citations
Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons
1998 • 225 citations
Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons
1998 • 224 citations
Signalling through the neurotrophin receptor p75NTR
1997 • 221 citations
Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord
1999 • 216 citations
p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure
1999 • 214 citations
Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis
1997 • 208 citations
Absence of p75NTRCauses Increased Basal Forebrain Cholinergic Neuron Size, Choline Acetyltransferase Activity, and Target Innervation
1997 • 206 citations
Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Stimulate Growth of Axonal Branches from Regenerating Retinal Ganglion Cells
1996 • 206 citations
An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.
1994 • 204 citations
NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation
1995 • 202 citations
NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR
2000 • 202 citations
TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death
1997 • 201 citations
Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses
1998 • 199 citations
Reduced Size of Retinal Ganglion Cell Axons and Hypomyelination in Mice Lacking Brain-Derived Neurotrophic Factor
1997 • 195 citations
A role for BDNF in mechanosensation
1998 • 194 citations
TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.
1996 • 194 citations
A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.
1991 • 193 citations
p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor
1999 • 193 citations
Evolution of the vertebrate neurotrophin and Trk receptor gene families
1999 • 190 citations
Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia
1998 • 189 citations
Neurotrophins Stimulate the Release of Dopamine from Rat Mesencephalic Neurons via Trk and p75Lntr Receptors
1996 • 187 citations
TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction
1999 • 185 citations
The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death
1999 • 185 citations
CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.
1994 • 182 citations
Trk Receptors Function As Rapid Retrograde Signal Carriers in the Adult Nervous System
1997 • 176 citations
NGF and Neurotrophin-3 Both Activate TrkA on Sympathetic Neurons but Differentially Regulate Survival and Neuritogenesis
1997 • 173 citations
SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.
1993 • 170 citations
Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae
1997 • 169 citations
The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea‐pig.
1978 • 169 citations
Caveolin Interacts with Trk A and p75NTR and Regulates Neurotrophin Signaling Pathways
1999 • 163 citations
Rapid Retrograde Tyrosine Phosphorylation of trkA and Other Proteins in Rat Sympathetic Neurons in Compartmented Cultures
1997 • 163 citations
TrkA, But Not TrkC, Receptors Are Essential for Survival of Sympathetic NeuronsIn Vivo
1996 • 162 citations
Emerging themes in structural biology of neurotrophic factors
1998 • 161 citations
Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons.
1995 • 160 citations
Insulin Receptor Substrate (IRS)-1 and IRS-2 Are Tyrosine-phosphorylated and Associated with Phosphatidylinositol 3-Kinase in Response to Brain-derived Neurotrophic Factor in Cultured Cerebral Cortical Neurons
1997 • 152 citations
An immunoglobulin-like domain determines the specificity of neurotrophin receptors.
1995 • 151 citations
Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis
1995 • 147 citations
BDNF Modulates, But Does Not Mediate, Activity-Dependent Branching and Remodeling of Optic Axon ArborsIn Vivo
1999 • 143 citations
BDNF Is a Target-Derived Survival Factor for Arterial Baroreceptor and Chemoafferent Primary Sensory Neurons
1999 • 143 citations
Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain
1995 • 138 citations
A splice variant of the neurotrophin receptor trkB with increased specificity for brain-derived neurotrophic factor.
1996 • 137 citations
p75NTR: A study in contrasts
1998 • 133 citations
A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.
1994 • 132 citations
Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor
1999 • 128 citations
Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway
1999 • 126 citations
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.
1998 • 123 citations
The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
1999 • 122 citations
Expression and function of TrkB variants in developing sensory neurons.
1996 • 114 citations
The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons
1999 • 111 citations
Identification of Maxillary Factor, a Maxillary Process–Derived Chemoattractant for Developing Trigeminal Sensory Axons
1999 • 103 citations
Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities
2000 • 100 citations
TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons
1998 • 97 citations
N-Shc and Sck, Two Neuronally Expressed Shc Adapter Homologs
1998 • 92 citations
Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system.
1994 • 90 citations
Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos
1997 • 85 citations
Sympathetic neurons in neonatal rats require endogenous neurotrophin-3 for survival
1995 • 85 citations
Early evolutionary origin of the neurotrophin receptor family
1998 • 81 citations
The Low-Affinity Neurotrophin Receptor p75 Regulates the Function But Not the Selective Survival of Specific Subpopulations of Sensory Neurons
1997 • 81 citations
Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation
1997 • 78 citations
Functional interaction of Fas‐associated phosphatase‐1 (FAP‐1) with p75NTR and their effect on NF‐κB activation
1999 • 78 citations
High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors
1998 • 78 citations
The Neurotrophin Receptor p75 Binds Neurotrophin-3 on Sympathetic Neurons with High Affinity and Specificity
1997 • 77 citations
CRNF, a Molluscan Neurotrophic Factor That Interacts with the p75 Neurotrophin Receptor
1996 • 76 citations
A function-structure model for NGF-activated TRK
1998 • 73 citations
A region of the 75 kDa neurotrophin receptor homologous to the death domains of TNFR‐I and Fas
1995 • 70 citations
Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons
2000 • 68 citations
The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells
1999 • 66 citations
Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors.
1993 • 63 citations
Identification, purification, and characterization of truncated forms of the human nerve growth factor receptor
1989 • 63 citations
A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.
1997 • 61 citations
The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279.
1994 • 59 citations
Identification of a conserved protein motif in a group of growth factor receptors
1990 • 57 citations
Interaction of mastoparan with the low molecular mass GTP‐binding proteins rho/rac
1991 • 57 citations
p75 Neurotrophin Receptor-mediated Neuronal Death Is Promoted by Bcl-2 and Prevented by Bcl-xL
1999 • 56 citations
p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase.
1996 • 53 citations
Differential Dependency of Unmyelinated and Aδ Epidermal and Upper Dermal Innervation on Neurotrophins, Trk Receptors, and p75LNGFR
1998 • 52 citations
CRK Protein Binds to Two Guanine Nucleotide-Releasing Proteins for the Ras Family and Modulates Nerve Growth Factor-Induced Activation of Ras in PC12 Cells
1994 • 50 citations
Increased formation of preganglionic synapses and axons due to a retrograde trans-synaptic action of nerve growth factor in the rat sympathetic nervous system
1983 • 45 citations
NGF Binding to p75 Enhances the Sensitivity of Sensory and Sympathetic Neurons to NGF at Different Stages of Development
1997 • 42 citations
SNT, a Differentiation-Specific Target of Neurotrophic Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 Cells
1993 • 36 citations
p75NGFR and cholinergic neurons in the developing forebrain: a re-examination
1999 • 36 citations
Brain-derived Neurotrophic Factor Induces Phosphorylation of Fibroblast Growth Factor Receptor Substrate 2
1999 • 33 citations
Ultrastructural Identification of Storage Compartments and Localization of Activity-Dependent Secretion of Neurotrophin 6 in Hippocampal Neurons
2000 • 23 citations
Nerve growth factor induces a multimeric TrkA receptor complex in neuronal cells that includes Crk, SHC and PLC-gamma 1 but excludes P130CAS.
1996 • 15 citations
TNF AND TNF RECEPTOR SUPERFAMILY
2001 • 2 citations