The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Genomic Libraries and a Host Strain Designed for Highly Efficient Two-Hybrid Selection in Yeast

1996 • 2,631 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

p75 and Trk: A two-receptor system

1995 • 861 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1996 • 750 citations

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

1990 • 720 citations

The nerve growth factor family of receptors

1992 • 649 citations

A family of proteins that inhibit signalling through tyrosine kinase receptors

1997 • 648 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Signal transduction by the neutrophin receptors

1997 • 573 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

1995 • 476 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

1994 • 397 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells

1994 • 353 citations

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

1998 • 322 citations

Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene

1985 • 306 citations

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1994 • 291 citations

Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.

1993 • 291 citations

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.

1991 • 255 citations

Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus

1992 • 225 citations

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities

1995 • 220 citations

Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis

1997 • 208 citations

The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.

1992 • 198 citations

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

1993 • 189 citations

Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent neural crest cells

1991 • 176 citations

The neurotrophins and their receptors

1993 • 173 citations

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.

1993 • 170 citations

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system.

1994 • 170 citations

Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins

1998 • 167 citations

Non-SH2 Domains within Insulin Receptor Substrate-1 and SHC Mediate Their Phosphotyrosine-dependent Interaction with the NPEY Motif of the Insulin-like Growth Factor I Receptor

1995 • 166 citations

Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis

1995 • 147 citations

A Reciprocal Cell–Cell Interaction Mediated by NT-3 and Neuregulins Controls the Early Survival and Development of Sympathetic Neuroblasts

1996 • 139 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.

1993 • 100 citations

Brain-derived Neurotrophic Factor Binding to the p75 Neurotrophin Receptor Reduces TrkA Signaling While Increasing Serine Phosphorylation in the TrkA Intracellular Domain

1997 • 79 citations

A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.

1997 • 61 citations

Deletions in the Extracellular Domain of Rat TrkA Lead to an Altered Differentiative Phenotype in Neurotrophin Responsive Cells

1996 • 41 citations

A Novel Juxtamembrane Deletion in Rat TrkA Blocks Differentiative but Not Mitogenic Cell Signaling in Response to Nerve Growth Factor

1998 • 39 citations

Transient Association of the Phosphotyrosine Phosphatase SHP‐2 with TrkA Is Induced by Nerve Growth Factor

1997 • 35 citations

A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor‐Dependent Cell Survival but Not Neurite Outgrowth

1997 • 31 citations