Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.

NCT03018236

PHASE4INTERVENTIONAL

Hospital de Clinicas de Porto Alegre

100 participants

Started 2017-01 · Completed 2018-12

Status: Unknown (as of 12-23-2025)

Conditions

Cocaine AddictionAlcohol Addiction

Interventions

DRUG: Alcohol N-acetylcysteine DRUG: Alcohol Placebo DRUG: Cocaine N-acetylcysteine DRUG: Cocaine Placebo

Linked Papers (from SciSciNet-V2)

Total Papers68

Background

22

Result

0

Derived

0

Unknown

46

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This study evaluates the use of N-acetylcysteine in the treatment of alcohol and cocaine use disorders. Alcohol users will be split in two groups, one will receive the active N-acetylcysteine and the other placebo. The same division will occur with cocaine users. The effects of N-acetylcysteine in adherence, abstinence, psychiatric symptoms and stress biomarkers will be evaluated.

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Background Papers44

Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder

Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

New Findings on Biological Factors Predicting Addiction Relapse Vulnerability

New Findings on Biological Factors Predicting Addiction Relapse Vulnerability

The neurobiology of cocaine addiction.

The neurobiology of cocaine addiction.

Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis

Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis

A Double-Blind Randomized Controlled Trial of N-Acetylcysteine in Cannabis-Dependent Adolescents

A Double-Blind Randomized Controlled Trial of N-Acetylcysteine in Cannabis-Dependent Adolescents

N-Acetylcysteine Reduces Extinction Responding and Induces Enduring Reductions in Cue- and Heroin-Induced Drug-Seeking

N-Acetylcysteine Reduces Extinction Responding and Induces Enduring Reductions in Cue- and Heroin-Induced Drug-Seeking

Brain-derived neurotrophic factor and cocaine addiction

Brain-derived neurotrophic factor and cocaine addiction

Glutamatergic medications for the treatment of drug and behavioral addictions

Glutamatergic medications for the treatment of drug and behavioral addictions

The genetics of addiction—a translational perspective

The genetics of addiction—a translational perspective

Safety and Tolerability of N‐Acetylcysteine in Cocaine‐Dependent Individuals

Safety and Tolerability of N‐Acetylcysteine in Cocaine‐Dependent Individuals

Shortened telomeres in individuals with abuse in alcohol consumption

Shortened telomeres in individuals with abuse in alcohol consumption

Ethanol–BDNF interactions: Still more questions than answers

Ethanol–BDNF interactions: Still more questions than answers

N-Acetylcysteine Normalizes Glutamate Levels in Cocaine-Dependent Patients: A Randomized Crossover Magnetic Resonance Spectroscopy Study

N-Acetylcysteine Normalizes Glutamate Levels in Cocaine-Dependent Patients: A Randomized Crossover Magnetic Resonance Spectroscopy Study

Addiction pharmacogenetics

Addiction pharmacogenetics

An Australian Twin Study of Cannabis and Other Illicit Drug Use and Misuse, and Other Psychopathology

An Australian Twin Study of Cannabis and Other Illicit Drug Use and Misuse, and Other Psychopathology

Drug addiction is associated with leukocyte telomere length

Drug addiction is associated with leukocyte telomere length

Total antioxidant capacity is significantly lower in cocaine‐dependent and methamphetamine‐dependent patients relative to normal controls: results from a preliminary study

Total antioxidant capacity is significantly lower in cocaine‐dependent and methamphetamine‐dependent patients relative to normal controls: results from a preliminary study

Protective effect of corn peptides against alcoholic liver injury in men with chronic alcohol consumption: a randomized double-blind placebo-controlled study

Protective effect of corn peptides against alcoholic liver injury in men with chronic alcohol consumption: a randomized double-blind placebo-controlled study

A population-based Swedish Twin and Sibling Study of cannabis, stimulant and sedative abuse in men

A population-based Swedish Twin and Sibling Study of cannabis, stimulant and sedative abuse in men

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers46

The fifth edition of the addiction severity index

4,196 citations

Assessment of Alcohol Withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA‐Ar)

1,830 citations

Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system

1,053 citations

Carcinogenicity of alcoholic beverages

Contingency management for treatment of substance use disorders: a meta‐analysis

A meta‐analysis of voucher‐based reinforcement therapy for substance use disorders

Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient Settings

Missing data in longitudinal studies

A New Measure of Substance Abuse Treatment Initial Studies of the Treatment Services Review

The promise of N-acetylcysteine in neuropsychiatry

Properties of the urn randomization in clinical trials

Profile of executive deficits in cocaine and heroin polysubstance users: common and differential effects on separate executive components

Contingency management in outpatient methadone treatment: a meta-analysis

Reliability and validity of the cocaine selective severity assessment

Selection models for repeated measurements with non-random dropout: an illustration of sensitivity

Mortality among cocaine users: A systematic review of cohort studies

Is Cocaine Desire Reduced by N -Acetylcysteine?

An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: A pilot study

N‐Acetyl Cysteine‐Induced Blockade of Cocaine‐Induced Reinstatement

Biomarkers in Substance Use Disorders

From neurobiology to treatment: progress against addiction

Psychometric properties of the sixth version of the Addiction Severity Index (ASI-6) in Brazil

Efficacy of N-Acetylcysteine in the Treatment of Nicotine Dependence: A Double-Blind Placebo-Controlled Pilot Study

A double-blind, placebo-controlled study of N-acetyl cysteine plus naltrexone for methamphetamine dependence

Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure

Key drug use, health and socio-economic characteristics of young crack users in two Brazilian cities

DNA damage in rats after treatment with methylphenidate

Clinical and biological moderators of response to naltrexone in alcohol dependence: a systematic review of the evidence

Brain-Derived Neurotrophic Factor Serum Levels in Alcohol-Dependent Subjects 6 Months After Alcohol Withdrawal

General Versus Systematic Inquiry about Emergent Clinical Events with SAFTEE

Association of Leukocyte Telomere Length with Type 2 Diabetes in Mainland Chinese Populations

Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal

Genetics of Dopamine and its Contribution to Cocaine Addiction

Environmental Oxidant Pollutant Effects on Biologic Systems

Excitatory Amino Acids in Epilepsy

Oxidative stress and BDNF as possible markers for the severity of crack cocaine use in early withdrawal

Increased Oxidative DNA Damage in Patients With Alcohol Dependence and Its Correlation With Alcohol Withdrawal Severity

Differential Patterns of Serum Brain-Derived Neurotrophic Factor Levels in Alcoholic Patients With and Without Delirium Tremens During Acute Withdrawal

Further psychometric study of the Beck Anxiety Inventory including factorial analysis and social anxiety disorder screening

N-acetylcysteine prevents behavioral and biochemical changes induced by alcohol cessation in rats

The correlation between early alcohol withdrawal severity and oxidative stress in patients with alcohol dependence

Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal

Getting a Knack for NAC: N-Acetyl-Cysteine.

Changes in brain-derived neurotrophic factor (BDNF) during abstinence could be associated with relapse in cocaine-dependent patients

Early abstinence of crack-cocaine is effective to attenuate oxidative stress and to improve antioxidant defences