p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

1989 • 934 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

Local control of neurite development by nerve growth factor

1977 • 732 citations

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

1990 • 720 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

1992 • 654 citations

The nerve growth factor family of receptors

1992 • 649 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

The house mouse

1972 • 555 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

1992 • 521 citations

Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development

1992 • 499 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

The house mouse. Development and normal stages from fertilization to 4 weeks of age.

1972 • 413 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

p75-Deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins

1993 • 359 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

1993 • 292 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

The response of chick sensory neurons to brain-derived neurotrophic factor

1986 • 251 citations

Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion

1984 • 225 citations

Nerve growth factor stimulates the development of substance P in sensory ganglia.

1980 • 198 citations

Neurotrophic factors promote the maturation of developing sensory neurons before they become dependent on these factors for survival

1992 • 195 citations

Requirement of nerve growth factor for development of substance P-containing sensory neurones

1980 • 194 citations

Neurotrophin 3 is a mitogen for cultured neural crest cells.

1992 • 192 citations

Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture.

1993 • 190 citations

Dependence of Kidney Morphogenesis on the Expression of Nerve Growth Factor Receptor

1991 • 184 citations

A new superfamily of cell surface proteins related to the nerve growth factor receptor

1991 • 172 citations

Nerve growth factor enhances dendritic arborization of sympathetic ganglion cells in developing mammals

1988 • 171 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

1992 • 166 citations

Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo

1988 • 142 citations

Developmental neuron death in the rat superior cervical sympathetic ganglion: cell counts and ultrastructure

1983 • 127 citations

Expression of the NGF receptor gene in sensory neurons and their cutaneous targets prior to and during innervation

1990 • 113 citations

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

1992 • 105 citations

Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons

1993 • 103 citations

Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons

1993 • 79 citations

The generation of neurons involved in an early reflex pathway of embryonic mouse spinal cord

1979 • 75 citations

Nerve growth factor stimulates the activities of the raf-1 and the mitogen-activated protein kinases via the trk protooncogene.

1992 • 68 citations

Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors

1991 • 63 citations

Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.

1991 • 62 citations

Nerve growth factor receptors on chick embryo sympathetic ganglion cells: binding characteristics and development

1986 • 59 citations

Identification of a conserved protein motif in a group of growth factor receptors

1990 • 57 citations

Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors.

1993 • 40 citations

Nerve growth factor induces the association of a 130-Kd phosphoprotein with its receptor in PC-12 pheochromocytoma cells.

1991 • 26 citations