Expression and function of TrkB variants in developing sensory neurons.

The Trk family of neurotrophin receptors

1994 • 1,271 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.

1993 • 685 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

Neurotrophin signal transduction by the Trk receptor

1994 • 511 citations

Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development

1992 • 499 citations

The role of neurotrophins in the developing nervous system

1994 • 472 citations

Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling

1996 • 472 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1995 • 413 citations

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

1995 • 381 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons

1993 • 338 citations

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

1993 • 290 citations

Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development

1995 • 270 citations

Role of neurotrophins in mouse neuronal development

1994 • 261 citations

Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

1993 • 259 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Regulation of neurotrophin receptors during the maturation of the mammalian visual system

1994 • 233 citations

Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion

1984 • 225 citations

Regulation of neurotrophin receptor expression during embryonic and postnatal development

1994 • 208 citations

Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

1994 • 207 citations

trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities.

1993 • 178 citations

Neurotrophic Factor Receptors and Their Signal Transduction Capabilities in Rat Astrocytes

1994 • 164 citations

Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus

1993 • 135 citations

Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS

1995 • 128 citations

Molecular and Biochemical Characterization of the Human trk Proto-Oncogene

1989 • 124 citations

The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation

1991 • 123 citations

Expression of the NGF receptor gene in sensory neurons and their cutaneous targets prior to and during innervation

1990 • 113 citations

Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling

1996 • 112 citations

Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons

1993 • 110 citations

Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons

1993 • 103 citations

The survival and growth of embryonic proprioceptive neurons is promoted by a factor present in skeletal muscle

1986 • 92 citations

Regulation of nerve growth factor receptor gene expression in sympathetic neurons during development.

1995 • 92 citations

Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth

1993 • 82 citations

The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development

1994 • 66 citations

Trigeminal Sensory Neurons Require Extrinsic Signals to Switch Neurotrophin Dependence during the Early Stages of Target Field Innervation

1995 • 54 citations

Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development

1994 • 50 citations

Heterotopic transplantation of presumptive placodal ectoderm changes the fate of sensory neuron precursors

1993 • 36 citations

NGF Receptor Expression in Sensory Neurons Develops Normally in Embryos Lacking NGF

1995 • 29 citations

Molecular cloning and expression of a novel truncated form of chicken trkC

1993 • 18 citations