The Developmental Biology of Brain Tumors
Data up to Jan 2025
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Abstract
References (320)
Mutation and Cancer: Statistical Study of Retinoblastoma
1971 • 7,335 citations
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
1999 • 6,443 citations
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
1997 • 5,665 citations
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 • 4,753 citations
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
1998 • 3,129 citations
The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
1998 • 3,053 citations
The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product
1989 • 3,036 citations
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
1986 • 2,968 citations
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
1997 • 2,746 citations
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 • 2,505 citations
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
1997 • 2,245 citations
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
1997 • 2,063 citations
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
1998 • 2,028 citations
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
1996 • 2,021 citations
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 • 1,972 citations
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
1996 • 1,850 citations
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
1982 • 1,790 citations
Effects of an Rb mutation in the mouse
1992 • 1,779 citations
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
1997 • 1,695 citations
ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
1998 • 1,584 citations
The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53
1998 • 1,538 citations
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
1990 • 1,531 citations
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
1985 • 1,523 citations
A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
1992 • 1,514 citations
Pten is essential for embryonic development and tumour suppression
1998 • 1,507 citations
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
1988 • 1,490 citations
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
1995 • 1,457 citations
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
1988 • 1,440 citations
Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence
1987 • 1,436 citations
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
2000 • 1,431 citations
Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog
1999 • 1,313 citations
Mechanisms and consequences of activation of protein kinase B/Akt
1998 • 1,305 citations
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
1992 • 1,285 citations
Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
2000 • 1,253 citations
Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN
1998 • 1,215 citations
Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis
1996 • 1,209 citations
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
1998 • 1,180 citations
The Multiple Roles of PTEN in Tumor Suppression
2000 • 1,150 citations
The Molecular Basis of Turcot's Syndrome
1995 • 1,116 citations
Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
1998 • 1,085 citations
Direct control of the Forkhead transcription factor AFX by protein kinase B
1999 • 1,080 citations
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
1995 • 1,016 citations
Requirement for a functional Rb-1 gene in murine development
1992 • 1,015 citations
Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway
1997 • 993 citations
Intracellular Signaling Pathways Activated by Neuropathic Factors
1996 • 958 citations
Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems
1999 • 941 citations
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.
1994 • 932 citations
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1998 • 906 citations
Sonic hedgehog regulates the growth and patterning of the cerebellum
1999 • 903 citations
Nevoid Basal-Cell Carcinoma Syndrome
1987 • 886 citations
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.
1997 • 883 citations
Development of the Cerebellar System: In Relation to Its Evolution, Structure, and Functions
1996 • 864 citations
Structural alterations of the epidermal growth factor receptor gene in human gliomas.
1992 • 853 citations
p53 and E2F-1 cooperate to mediate apoptosis.
1994 • 844 citations
Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300
1999 • 841 citations
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1998 • 823 citations
Structural Evidence for the Authenticity of the Human Retinoblastoma Gene
1987 • 809 citations
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
1999 • 787 citations
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
1997 • 778 citations
Regulation ofp53downstream genes
1998 • 777 citations
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 • 772 citations
Protein tyrosine phosphatases in signal transduction
1997 • 766 citations
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 • 765 citations
Cognitive and language functions of the human cerebellum
1993 • 728 citations
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
1999 • 703 citations
PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond
1997 • 699 citations
The Rx homeobox gene is essential for vertebrate eye development
1997 • 699 citations
Distinct roles for E2F proteins in cell growth control and apoptosis
1997 • 694 citations
Bone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells
1996 • 681 citations
Lineage-independent determination of cell type in the embryonic mouse retina
1990 • 656 citations
The oncogenic activation of β-catenin
1999 • 655 citations
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
1998 • 652 citations
Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
1999 • 646 citations
Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene
1992 • 643 citations
Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.
1991 • 634 citations
Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.
1992 • 609 citations
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.
1990 • 593 citations
The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.
1996 • 592 citations
Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family
1989 • 586 citations
A self-renewing multipotential stem cell in embryonic rat cerebral cortex
1994 • 578 citations
Regulation of G1progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
1999 • 572 citations
Sporadic medulloblastomas contain PTCH mutations.
1997 • 567 citations
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
1998 • 560 citations
The world according to bedgebog
1997 • 549 citations
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999 • 539 citations
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
1999 • 528 citations
Signal transduction by bone morphogenetic proteins
1998 • 528 citations
From Form to Function: Signaling by Protein Tyrosine Phosphatases
1996 • 526 citations
Impaired Fas Response and Autoimmunity in Pten +/− Mice
1999 • 512 citations
Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation
1996 • 506 citations
Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy
1994 • 493 citations
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
1998 • 479 citations
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
1998 • 449 citations
DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours
1997 • 444 citations
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.
1994 • 439 citations
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
1997 • 437 citations
Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten
1999 • 418 citations
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
1999 • 415 citations
Bone morphogenetic proteins in the nervous system
1997 • 409 citations
The retinoblastoma gene family in differentiation and development
1999 • 409 citations
Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch
1995 • 409 citations
In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor
1988 • 408 citations
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
1998 • 395 citations
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.
1998 • 393 citations
Multiple Routes to Astrocytic Differentiation in the CNS
1998 • 389 citations
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
2000 • 378 citations
The type 1 (EGFR-related) family of growth factor receptors and their ligands
1992 • 377 citations
Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos
1998 • 375 citations
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.
1997 • 374 citations
Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells
1997 • 369 citations
PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway
1999 • 367 citations
Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.
1975 • 353 citations
Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-X L and caspase-3-like proteases
1998 • 348 citations
Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture
1988 • 343 citations
Expression of a Dominant Negative FGF Receptor Inhibits Axonal Growth and FGF Receptor Phosphorylation Stimulated by CAMs
1997 • 335 citations
Targeted disruption of p107: functional overlap between p107 and Rb.
1996 • 333 citations
Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.
1996 • 325 citations
Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation
1999 • 324 citations
A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor
1998 • 320 citations
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
1999 • 317 citations
p107 is a suppressor of retinoblastoma development in pRb-deficient mice
1998 • 316 citations
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.
1997 • 315 citations
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.
1998 • 313 citations
A tripotential glial precursor cell is present in the developing spinal cord
1998 • 311 citations
Neurons, astrocytes, and oligodendrocytes of the rat cerebral cortex originate from separate progenitor cells: an ultrastructural analysis of clonally related cells
1993 • 311 citations
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.
1994 • 310 citations
The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates
1999 • 308 citations
Inhibition of GSK-3β leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium
1998 • 307 citations
Rod photoreceptor development in vitro: Intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina
1990 • 299 citations
p300 and CBP: Partners for life and death
1999 • 299 citations
Neuroepithelial Stem Cells from the Embryonic Spinal Cord: Isolation, Characterization, and Clonal Analysis
1997 • 298 citations
EGF receptor in neoplasia and metastasis
1993 • 297 citations
Bone Morphogenetic Proteins Induce Astroglial Differentiation of Oligodendroglial–Astroglial Progenitor Cells
1997 • 293 citations
Glial-Restricted Precursors Are Derived from Multipotent Neuroepithelial Stem Cells
1997 • 287 citations
Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.
2000 • 286 citations
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.
1994 • 286 citations
The INK4a/ARF tumor suppressor: one gene—two products—two pathways
1998 • 286 citations
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.
1997 • 284 citations
APC Mutations in Sporadic Medulloblastomas
2000 • 283 citations
Astrocytes: Form, Functions, and Roles in Disease
1994 • 278 citations
Multipotent and restricted precursors in the central nervous system
1999 • 269 citations
Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.
1996 • 267 citations
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.
1997 • 266 citations
Hedgehog and Patched in Neural Development and Disease
1998 • 259 citations
Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification.
1994 • 255 citations
Changes in retinal cell fate induced by overexpression of EGF receptor
1995 • 248 citations
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
1998 • 244 citations
Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B
1999 • 242 citations
Swaying is a mutant allele of the proto-oncogene Wnt-1
1991 • 242 citations
Proliferation and migration of undifferentiated precursor cells in the rat during postnatal gliogenesis
1966 • 241 citations
Development of the Cerebellar System
1997 • 234 citations
Multiple functions for Pax6 in mouse eye and nasal development.
1996 • 231 citations
Retinoblastoma—origin from a primitive neuroectodermal cell?
1984 • 229 citations
Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.
1996 • 229 citations
Multipotential stem cells and progenitors in the vertebrate retina
1998 • 222 citations
Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
1998 • 220 citations
Cell lineage analysis reveals multipotent precursors in the ciliary margin of the frog retina
1989 • 219 citations
A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum
1995 • 218 citations
Molecular pathogenesis of malignant gliomas
1999 • 217 citations
Nuclear Localization and Mutation of β-Catenin in Medulloblastomas
2000 • 215 citations
Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter.
1992 • 213 citations
Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice
1992 • 211 citations
Developmental Changes in Progenitor Cell Responsiveness to Bone Morphogenetic Proteins Differentially Modulate Progressive CNS Lineage Fate
2000 • 207 citations
Gliogenesis in the central nervous system
2000 • 207 citations
The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
2000 • 206 citations
Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system
1982 • 206 citations
Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor
1998 • 205 citations
Role of the Rb/E2F pathway in cell growth control
1997 • 203 citations
Growth and Fate of PSA-NCAM+ Precursors of the Postnatal Brain
1998 • 202 citations
Local Control of Granule Cell Generation by Cerebellar Purkinje Cells
1995 • 200 citations
Mechanisms of glial-guided neuronal migration in vitro and in vivo
1990 • 199 citations
Catching a Gli-mpse of Hedgehog
1997 • 198 citations
Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar cultures
1981 • 197 citations
Purification and Characterization of Astrocyte Precursor Cells in the Developing Rat Optic Nerve
1999 • 193 citations
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
1998 • 190 citations
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.
1998 • 190 citations
Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors
1999 • 189 citations
PTEN Gene and Integrin Signaling in Cancer
1999 • 186 citations
Astrocyte-induced modulation of synaptic transmission
1999 • 183 citations
Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
1998 • 181 citations
Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts
1997 • 176 citations
In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
1998 • 173 citations
DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer.
2000 • 170 citations
Astrocytes as mediators of immune and inflammatory responses in the CNS.
1998 • 169 citations
Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells.
1995 • 166 citations
Necdin, A Postmitotic Neuron-specific Growth Suppressor, Interacts with Viral Transforming Proteins and Cellular Transcription Factor E2F1
1998 • 163 citations
A Family of Putative Tumor Suppressors Is Structurally and Functionally Conserved in Humans and Yeast
1997 • 159 citations
New views on synapse—glia interactions
1996 • 157 citations
Age of differentiation determines rat retinal germinal cell phenotype: induction of differentiation by dissociation
1989 • 157 citations
Amplification and Expression of Cyclin D Genes (CCND1 CCND2 and CCND3) in Human Malignant Gliomas
1999 • 155 citations
Structure, expression and function of a schwannoma-derived growth factor
1990 • 153 citations
The history of radial glia
1999 • 149 citations
Cell cycle regulators in neural stem cells and postmitotic neurons
2000 • 148 citations
Cellular interactions determine neuronal phenotypes in rodent retinal cultures
1992 • 144 citations
Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor
1998 • 143 citations
Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in vitro simulation.
1996 • 143 citations
Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma.
1996 • 143 citations
Deregulated expression of PAX5 in medulloblastoma.
1995 • 141 citations
Long-Term Culture of Purified Postnatal Oligodendrocyte Precursor Cells
2000 • 139 citations
NEONATAL CEREBELLAR MEDULLOBLASTOMA ORIGINATING FROM THE FETAL EXTERNAL GRANULAR LAYER
1970 • 138 citations
The retinoblastoma gene family is differentially expressed during embryogenesis
1997 • 138 citations
Astrocyte differentiation mediated by LIF in cooperation with BMP2
1999 • 136 citations
Effect of epidermal growth factor on membrane motility and cell locomotion in cultures of human clonal glioma cells
1982 • 135 citations
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4
1997 • 134 citations
Chromosomal characteristics of childhood brain tumors
1997 • 132 citations
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis
1999 • 131 citations
A detailed analysis of chromosomal changes in heritable and non-heritable retinoblastoma
1985 • 129 citations
Regional Distribution of Sonic Hedgehog, Patched, and Smoothened mRNA in the Adult Rat Brain
1998 • 123 citations
Modulation of cellular apoptotic potential: contributions to oncogenesis
1999 • 123 citations
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.
1999 • 121 citations
PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein
1999 • 120 citations
Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors
2000 • 120 citations
A Role for Transforming Growth Factor α as an Inducer of Astrogliosis
1998 • 118 citations
Amplification and overexpression of the egf receptor gene in primary human glioblastomas
1985 • 117 citations
Loss of heterozygosity for 10q loci in human gliomas
1992 • 115 citations
Glia, neurons, and axon pathfinding during optic chiasm development
1997 • 113 citations
Dorsal Spinal Cord Neuroepithelium Generates Astrocytes but Not Oligodendrocytes
1998 • 112 citations
Repression by the Mad(Mxi1)-Sin3 complex
1998 • 110 citations
NRP/B, a Novel Nuclear Matrix Protein, Associates With p110RB and Is Involved in Neuronal Differentiation
1998 • 109 citations
Soluble factors and the development of rod photoreceptors
2000 • 109 citations
The patched signaling pathway in tumorigenesis and development: lessons from animal models
1999 • 109 citations
Regulation of eye formation by the Rx and pax6 homeobox genes
2000 • 108 citations
Speculations on the roles of RB1 in tissue‐specific differentiation, tumor initiation, and tumor progression
1993 • 107 citations
The genesis of cancer : a study in the history of ideas
1978 • 107 citations
Ciliary neurotrophic factor: A review
1994 • 105 citations
Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord
1999 • 104 citations
Multiple trophic actions of heparin‐binding epidermal growth factor (HB‐EGF) in the central nervous system
1999 • 103 citations
Cell cycle targets of the DNA tumor viruses
1994 • 101 citations
A Critical Temporal Requirement for the Retinoblastoma Protein Family During Neuronal Determination
1998 • 100 citations
The role of glial cells in synaptic function
1999 • 100 citations
Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas
1998 • 98 citations
MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells.
1997 • 98 citations
Tumor suppressor genes and medulloblastoma
1996 • 97 citations
Nonrandom chromosomal changes in untreated retinoblastomas
1983 • 93 citations
Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance.
1998 • 90 citations
Arrest of Cell Growth by Necdin, a Nuclear-Protein Expressed in Postmitotic Neurons
1995 • 90 citations
Localization and characterization of PACAP receptors in the rat cerebellum during development: Evidence for a stimulatory effect of PACAP on immature cerebellar granule cells
1993 • 88 citations
Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain
1992 • 88 citations
Constitutive Overexpression of CDK2 Inhibits Neuronal Differentiation of Rat Pheochromocytoma PC12 Cells
1995 • 87 citations
A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
1999 • 87 citations
Adenovirus-mediated p53 Gene Therapy for Human Gliomas
1999 • 87 citations
Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system
1997 • 85 citations
Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins.
1995 • 83 citations
Neuronal Cdc2-like Kinase (Nclk) Binds and Phosphorylates the Retinoblastoma Protein
1997 • 80 citations
Mechanisms of astrocyte-directed neurite guidance
1997 • 79 citations
Expression patterns of the E2F family of transcription factors during mouse nervous system development
1997 • 78 citations
Expression of pituitary adenylate cyclase activating polypeptide (PACAP) in the postnatal and adult rat cerebellar cortex
1998 • 77 citations
Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression
1998 • 77 citations
Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells.
1993 • 76 citations
Development of the mammalian retina
1993 • 76 citations
Neural Precursor Cells Differentiating in the Absence of Rb Exhibit Delayed Terminal Mitosis and Deregulated E2F 1 and 3 Activity
1999 • 76 citations
Chromosomal abnormalities in human retinoblastoma a review
1986 • 74 citations
Retinoblastoma
1995 • 74 citations
U.S. childhood cancer survival, 1973–1987
1994 • 74 citations
Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators
1996 • 74 citations
In Vivo Viability of Postmitotic Purkinje Neurons Requires pRb Family Member Function
1995 • 72 citations
Differentiation of human retinoblastoma in vitro into cell types with characteristics observed in embryonal or mature retina.
1986 • 72 citations
Inhibition of glycogen synthase kinase 3β activity regulates proliferation of cultured cerebellar granule cells
1998 • 71 citations
Role of Cyclins in Neuronal Differentiation of Immortalized Hippocampal Cells
1997 • 71 citations
Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region
1998 • 70 citations
Bipotent Cortical Progenitor Cells Process Conflicting Cues for Neurons and Glia in a Hierarchical Manner
1999 • 69 citations
Cell Cycle Regulation of the Transcriptional Coactivators p300 and CREB Binding Protein
1998 • 69 citations
Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network
1999 • 68 citations
Similar chromosomal abnormalities in several retinoblastomas
1982 • 66 citations
Viral oncoprotein binding to pRB, p107, p130, and p300
1995 • 64 citations
Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme.
1998 • 62 citations
Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development
1999 • 61 citations
Bone Morphogenetic Proteins Induce Differentiation in Astrocyte Lineage Cells
1994 • 59 citations
Signaling mechanisms of cytokine receptors and their perturbances in disease
2000 • 59 citations
Restoration of Wild-type PTEN Expression Leads to Apoptosis, Induces Differentiation, and Reduces Telomerase Activity in Human Glioma Cells
1999 • 59 citations
Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma
1996 • 58 citations
Upregulation of phospholipase D in astrocytes in response to transient forebrain ischemia
2000 • 57 citations
Functional and molecular analyses of 10q deletions in human gliomas
1999 • 56 citations
Suppression of human glioma growth by adenovirus-mediated Rb gene transfer
1998 • 55 citations
Marked inhibition of glioblastoma target cell tumorigenicity in vitro by retrovirus-mediated transfer of a hairpin ribozyme against deletion-mutant epidermal growth factor messenger RNA
2000 • 53 citations
From rodent glial precursor cell to human glial neoplasia in the oligodendrocyte‐type‐2‐astrocyte lineage
1995 • 49 citations
Functional evidence for a role of combined CDKN2A (p16-p14 ARF )/ CDKN2B (p15) gene inactivation in malignant gliomas
1999 • 49 citations
Isolation, cloning and characterization of a putative type-1 astrocyte cell line
1997 • 47 citations
Regulation of Expression and Activity of Distinct pRB, E2F, D-Type Cyclin, and CKI Family Members during Terminal Differentiation of P19 Cells
1998 • 47 citations
Retinoblastoma: a primitive tumor with multipotential characteristics.
1986 • 47 citations
Gliogenesis in the prenatal rabbit spinal cord.
1982 • 46 citations
Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile.
1995 • 46 citations
Genetic alterations in glioma and medulloblastoma
1991 • 44 citations
Interfering with the Pathologic Activation of Microglial Cells and Astrocytes in Dementia
1998 • 44 citations
Neuronal Cdc2-like kinases: Neuron-specific forms of Cdk5
1997 • 43 citations
Glioblastoma and malignant astrocytoma
2011 • 42 citations
Cell cycle arrest and astrocytic differentiation resulting from PTEN expression in glioma cells
1999 • 41 citations
The role of the epidermal growth factor receptor in human gliomas: I. The control of cell growth
1995 • 40 citations
Apoptosis Induced by the Nuclear Death Domain Protein p84N5 Is Inhibited by Association with Rb Protein
1999 • 39 citations
Mechanisms of Progenitor Maturation Are Conserved in the Striatum and Cortex
2000 • 38 citations
Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo
2000 • 35 citations
The Highly Integrated Dialogue between Neurons and Astrocytes in Brain Function
1999 • 35 citations
Primary Degeneration of the Granular Layer of the Cerebellum. A Study of 14 Patients and Review of the Literature
1994 • 34 citations
Targeting in Gene Therapy for Gliomas
1999 • 34 citations
Genetic sequences that predispose to retinoblastoma and osteosarcoma.
1986 • 34 citations
Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor.
2000 • 34 citations
Cerebellar mutant mice and chimeras revisited.
1997 • 33 citations
Neuronal Cdc2-like kinase: from cell cycle to neuronal function
1996 • 32 citations
Gene therapy for gliomas: p53 and E2F-1 proteins and the target of apoptosis.
1999 • 32 citations
Chapter 15: Early response gene induction in astrocytes as a mechanism for encoding and integrating neuronal signals
1992 • 31 citations
The Transcription Factor E2F-1 in SV40 T Antigen-Induced Cerebellar Purkinje Cell Degeneration
1998 • 29 citations
The role of epidermal growth factor receptor in human gliomas: II. The control of glial process extension and the expression of glial fibrillary acidic protein
1995 • 29 citations
Multipotent and restricted precursors in the central nervous system
1999 • 29 citations
Multiple genetic loci modify risk for retinoblastoma in transgenic mice.
1998 • 29 citations
Differential neurite growth on astrocyte substrates: interspecies facilitation in green fluorescent protein-transfected rat and human neurons
1999 • 29 citations
Role of target antigen in bispecific-antibody-mediated killing of human glioblastoma cells: A pre-clinical study
1999 • 28 citations
Genetics of embryonal tumours of childhood: retinoblastoma, Wilms' tumour and neuroblastoma.
1995 • 24 citations
Development of Purkinje cell bodies and processes with basic fibroblast growth factor-like immunoreactivity in the rat cerebellum
1994 • 24 citations
Susceptibility to Cell Death Induced by Mutant SV40 T-Antigen Correlates with Purkinje Neuron Functional Development
1997 • 23 citations
Astrocyte-induced modulation of synaptic transmission
1999 • 23 citations
Antisense epidermal growth factor receptor RNA transfection in human malignant glioma cells leads to inhibition of proliferation and induction of differentiation
1998 • 22 citations
Pituitary adenylate cyclase activating polypepetide is expressed by developing rat Purkinje cells and decreases the number of cerebellar γ-amino butyric acid positive neurons in culture
1999 • 19 citations
Transient accumulation of retinoblastoma/E2F-1 protein complexes correlates with the onset of neuronal differentiation in the developing quail neural retina.
1998 • 17 citations
Mutations of TP53, amplification of EGFR, MDM2 and CDK4, and deletions of CDKN2A in malignant astrocytomas.
1998 • 13 citations
Photoreceptor differentiation of retinoblastoma: An electron microscopic study of 29 retinoblastomas
1994 • 13 citations
Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor
1998 • 11 citations
A quantitative histological study of cell division and changes in cell number in the meningeal sheath of the embryonic human optic nerve.
1987 • 6 citations
Role of target antigen in bispecific‐antibody‐mediated killing of human glioblastoma cells: A pre‐clinical study
1999 • 4 citations
Repression by the Mad(Mxi1)‐Sin3 complex
1998 • 4 citations
Loss of Heterozygosity in the VNTR Region of Intron 1 of P53 in two Retinoblastoma Cases
1996 • 3 citations