Regulation ofp53downstream genes

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

1998 • 752 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

1997 • 725 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

1997 • 529 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

1995 • 426 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1991 • 391 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

1996 • 346 citations

Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

1994 • 315 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control

1998 • 294 citations

A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

1997 • 285 citations

p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription

1998 • 284 citations

Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.

1998 • 258 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity

1998 • 229 citations

Wild-type p53 negatively regulates the expression of a microtubule-associated protein.

1996 • 223 citations

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1998 • 194 citations

p21/p53, Cellular Growth Control and Genomic Integrity

1998 • 177 citations

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1997 • 171 citations

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.

1998 • 160 citations

p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.

1998 • 158 citations

Involvement of p85 in p53-dependent apoptotic response to oxidative stress

1998 • 154 citations

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding

1998 • 152 citations

Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.

1996 • 144 citations

p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta.

1997 • 130 citations

HIC1 hypermethylation is a late event in hematopoietic neoplasms.

1997 • 118 citations

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

1998 • 116 citations

A novel p53-inducible gene coding for a microtubule-localized protein with G2-phase-specific expression

1998 • 92 citations

Repression of the basal c-fos promoter by wild-type p53

1992 • 92 citations

Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells.

1996 • 79 citations

p53 represses Sp1 DNA binding and HIV-LTR directed transcription.

1997 • 74 citations

Wig-1, a new p53-induced gene encoding a zinc finger protein

1997 • 67 citations

Transcriptional repression by the C-terminal domain of p53.

1995 • 61 citations

Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system

1998 • 60 citations

The Tumor Suppressor p53 Is a Negative Regulator of Estrogen Receptor Signaling Pathways

1997 • 58 citations

Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis

1997 • 58 citations

Wild‐type murine p53 represses transcription from the murine c‐myc promoter in a human glial cell line

1992 • 56 citations

Tumor Suppressor p53 Is a Negative Regulator in Thyroid Hormone Receptor Signaling Pathways

1997 • 55 citations

Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity.

1996 • 55 citations

Upregulation of the Elongation Factor-1α Gene by p53 in Association With Death of an Erythroleukemic Cell Line

1997 • 53 citations

p53 suppresses cytokine induced, Stat5 mediated activation of transcription

1998 • 27 citations

Repression of Interleukin-2 and Interleukin-4 Promoters by Tumor Suppressor Protein p53

1996 • 24 citations

Deleted Work

1955 • 0 citations