Amplification and Expression of Cyclin D Genes (CCND1 CCND2 and CCND3) in Human Malignant Gliomas

Histological Typing of Tumours of the Central Nervous System

1993 • 1,493 citations

Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer

1992 • 1,413 citations

D-type cyclins

1995 • 978 citations

Greenfield's Neuropathology

1997 • 811 citations

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

1996 • 700 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.

1998 • 583 citations

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

1994 • 439 citations

Cyclin D1 and human neoplasia

1998 • 336 citations

Quantitative analysis of comparative genomic hybridization

1995 • 304 citations

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.

1996 • 267 citations

Genomic organization, chromosomal localization, and independent expression of human cyclin D genes

1992 • 264 citations

Amplification of cyclin genes in colorectal carcinomas.

1993 • 197 citations

The p53 gene and its role in human brain tumors

1995 • 188 citations

Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses.

1994 • 180 citations

Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.

1996 • 175 citations

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

1997 • 174 citations

Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines.

1995 • 166 citations

Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization.

1996 • 159 citations

Gene and chromosomal alterations associated with the development of human gliomas

1993 • 107 citations

Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization.

1996 • 102 citations

[22] Detection of chromosomal aberrations by means of molecular cytogenetics: Painting of chromosomes and chromosomal subregions and comparative genomic hybridization

1995 • 94 citations

High-level DNA amplifications are common genetic aberrations in B-cell neoplasms.

1997 • 87 citations

Frequent In activation of CDKN2A and Rare Mutation of TP53 in PCNSL

1998 • 72 citations

Advances in the molecular genetics of gliomas

1997 • 57 citations

Cyclin D1 expression in gliomas

1998 • 38 citations

Cyclin D1/PRAD1 as a central target in oncogenesis

1996 • 33 citations

Cyclin D1 in astrocytic tumours: an immunohistochemical study

1996 • 30 citations