Multiple Routes to Astrocytic Differentiation in the CNS

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Stem Cells in the Central Nervous System

1997 • 1,483 citations

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1996 • 1,164 citations

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

1997 • 993 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Identification of major cell classes in the developing mammalian nervous system

1985 • 803 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Bone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells

1996 • 681 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

1995 • 583 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Proliferation and differentiation of rat neuroepithelial precursor cells in vivo

1988 • 563 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus

1993 • 177 citations

Extracellular matrix-associated molecules collaborate with ciliary neurotrophic factor to induce type-2 astrocyte development.

1990 • 155 citations

Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein.

1991 • 149 citations

Leukemia Inhibitory Factor Is Expressed in Astrocytes Following Cortical Brain Injury

1997 • 130 citations

Ciliary Neurotrophic Factor Activates JAK/Stat Signal Transduction Cascade and Induces Transcriptional Expression of Glial Fibrillary Acidic Protein in Glial Cells

1997 • 106 citations

Intracellular signalling: Putting JAKs on the kinase MAP

1996 • 93 citations

STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines.

1994 • 90 citations

STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines

1994 • 54 citations

STAT proteins are activated by ciliary neurotrophic factor in cells of central nervous system origin

1996 • 49 citations

LIF-mediated activation of STAT proteins after neuronal injury in vivo

1995 • 45 citations