The role of the epidermal growth factor receptor in human gliomas: I. The control of cell growth

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

Cellular Transforming Genes

1982 • 622 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Expression of epidermal growth factor receptors in human brain tumors.

1984 • 478 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 467 citations

Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies

1984 • 443 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma Cells

1984 • 400 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

Relation of epidermal growth factor receptor concentration to growth of human epidermoid carcinoma A431 cells.

1984 • 245 citations

Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro.

1990 • 229 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer.

1986 • 192 citations

Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.

1983 • 168 citations

Growth and Chemotherapeutic Response in Athymic Mice of Tumors Arising from Human Glioma-derived Cell Lines

1981 • 160 citations

Oncogenes of Spontaneous and Chemically Induced Tumors

1982 • 152 citations

Genetic suppression of tumor formation: a new frontier in cancer research.

1986 • 152 citations

Vasopressin inhibition of epidermal growth factor binding to cultured mouse cells.

1981 • 130 citations

Platelet-derived growth factor treatment decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells.

1983 • 129 citations

Growth factors and transformation.

1986 • 128 citations

Tumor suppressors: Recessive mutations that lead to cancer

1988 • 115 citations

Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variants.

1987 • 114 citations

Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells.

1992 • 110 citations

Inhibition of epidermal growth factor binding to mouse cultured cells by fibroblast-derived growth factor. Evidence for an indirect mechanism.

1982 • 90 citations

Epidermal growth factor receptor expression in human gliomas

1991 • 79 citations

Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

1988 • 64 citations

Modulation of growth and epidermal growth factor receptor activity by retinoic acid in human glioma cells.

1989 • 64 citations

A PLATELET‐DERIVED GROWTH FACTOR ANALOG PRODUCED BY A HUMAN CLONAL GLIOMA CELL LINE*

1982 • 62 citations

Growth effects of epidermal growth factor (EGF) and a monoclonal antibody against the EGF receptor on four glioma cell lines

1988 • 59 citations

Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium

1990 • 59 citations

Transforming growth factor-α, epidermal growth factor receptor, and proliferating potential in benign and malignant gliomas

1991 • 57 citations

Growth factors in cultured human glioma cells: Differential effects of FGF, EGF and PDGF☆

1988 • 56 citations

Growth Factors and Oncogenes in Human Malignant Glioma

1985 • 51 citations

Oncogenes and growth control 1987

1987 • 50 citations

Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells

1985 • 38 citations

The effects of type beta transforming growth factor on proliferation and epidermal growth factor receptor expression in a human glioblastoma cell line

1988 • 31 citations

Proto-oncogene abnormalities and their relationship to tumorigenicity in some human glioblastomas

1989 • 22 citations

Enhancement of Growth of Primary Metastatic Fresh Human Tumors of the Nervous System by Epidermal Growth Factor in Serum-free Short Term Culture

1988 • 12 citations