The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Pathology of Tumours of the Nervous System

1990 • 3,462 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

1995 • 1,720 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Pathology of Tumors of the Nervous System.

1964 • 1,494 citations

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

1999 • 1,313 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Sonic hedgehog regulates the growth and patterning of the cerebellum

1999 • 903 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Nevoid Basal-Cell Carcinoma Syndrome

1987 • 886 citations

Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome

1997 • 880 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog

1997 • 712 citations

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

1997 • 702 citations

Identification of an Amplified, Highly Expressed Gene in a Human Glioma

1987 • 671 citations

Mechanisms of Neural Patterning and Specification in the Development Cerebellum

1995 • 574 citations

Sporadic medulloblastomas contain PTCH mutations.

1997 • 567 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

1998 • 449 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

1997 • 374 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

Regulation of patched by sonic hedgehog in the developing neural tube.

1996 • 331 citations

Sonic hedgehog signaling by the Patched–Smoothened receptor complex

1999 • 326 citations

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.

1997 • 315 citations

Identification of Mutations in the Human PATCHED Gene in Sporadic Basal Cell Carcinomas and in Patients with the Basal Cell Nevus Syndrome

1998 • 307 citations

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

1997 • 302 citations

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

1997 • 277 citations

Hedgehog and Patched in Neural Development and Disease

1998 • 259 citations

Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.

1994 • 244 citations

Amplification of the gli gene in childhood sarcomas.

1989 • 218 citations

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

1994 • 212 citations

Analysis ofPTCH/SMO/SHH pathway genes in medulloblastoma

2000 • 189 citations

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours

1997 • 188 citations

Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization.

1997 • 163 citations

The gene for the naevoid basal cell carcinoma syndrome acts as a tumour-suppressor gene in medulloblastoma

1997 • 131 citations

Cytogenetic rearrangements involving the loss of the Sonic Hedgehog gene at 7q36 cause holoprosencephaly

1997 • 117 citations

Primitive Neuroectodermal Tumors of the Central Nervous System

1997 • 98 citations

Tumor suppressor genes and medulloblastoma

1996 • 97 citations

Recent advances in hedgehog signalling

1997 • 84 citations

Genetics of Pediatric Central Nervous System Tumors

1997 • 56 citations