The Multiple Roles of PTEN in Tumor Suppression

Cellular survival: a play in three Akts

1999 • 4,229 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Crystal Structure of the PTEN Tumor Suppressor

1999 • 1,011 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

1997 • 883 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1999 • 317 citations

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

1999 • 312 citations

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

1999 • 275 citations

PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.

1999 • 253 citations

PTEN Gene and Integrin Signaling in Cancer

1999 • 186 citations

The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.

1999 • 120 citations

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein

1999 • 120 citations