Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1993 • 884 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

Phosphoinositide kinases

1996 • 529 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 • 470 citations

Cloning and Characterization of Three Human Forkhead Genes That Comprise an FKHR-like Gene Subfamily

1998 • 350 citations

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

1998 • 336 citations

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

1994 • 332 citations

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

1992 • 300 citations

Protein-Protein Interaction of Zinc Finger LIM Domains with Protein Kinase C

1996 • 248 citations

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

1997 • 247 citations

Direct Visualization of the Translocation of the γ-Subspecies of Protein Kinase C in Living Cells Using Fusion Proteins with Green Fluorescent Protein

1997 • 228 citations

AF6q21, a Novel Partner of the MLL Gene in t(6; 11)(q21; q23), Defines a Forkhead Transcriptional Factor Subfamily

1997 • 215 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

1999 • 179 citations

PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1

1999 • 146 citations

Three Distinct Mechanisms for Translocation and Activation of the δ Subspecies of Protein Kinase C

1998 • 135 citations

Dominant Negative Forms of Akt (Protein Kinase B) and Atypical Protein Kinase Cλ Do Not Prevent Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 101 citations

The Pleckstrin Homology Domain of RAC Protein Kinase Associates with the Regulatory Domain of Protein Kinase C ζ

1994 • 98 citations

Molecular Cloning of Rat RAC Protein Kinase α and β and Their Association with Protein Kinase Cζ

1994 • 71 citations

Structure of 85 kDa Subunit of Human Phosphatidylinositol 3‐Kinase Analyzed by Using Monoclonal Antibodies

1993 • 22 citations