The world according to bedgebog

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

The development of Drosophila melanogaster

1994 • 3,057 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

A molecular pathway determining left-right asymmetry in chick embryogenesis

1995 • 781 citations

Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

1995 • 719 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 • 664 citations

Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos

1996 • 653 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

1995 • 557 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube

1995 • 542 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut

1995 • 531 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.

1995 • 504 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

1995 • 489 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

1994 • 451 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

Midline signalling is required for Pax gene regulation and patterning of the eyes

1995 • 433 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1996 • 351 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish

1996 • 320 citations

Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus

1996 • 320 citations

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

1995 • 309 citations

Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning

1996 • 299 citations

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb

1996 • 298 citations

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

1994 • 298 citations

Roles of wingless in patterning the larval epidermis of Drosophila

1991 • 295 citations

Induction of floor plate differentiation by contact-dependent, homeogenetic signals

1993 • 271 citations

hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila

1996 • 269 citations

Hedgehog, Transmitted along Retinal Axons, Triggers Neurogenesis in the Developing Visual Centers of the Drosophila Brain

1996 • 255 citations

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

1992 • 248 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis

1995 • 200 citations

Growth and differentiation in the Drosophila eye coordinated by hedgehog

1995 • 199 citations

A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog

1995 • 198 citations

Cloning, Expression, and Chromosomal Location of SHH and IHH: Two Human Homologues of the Drosophila Segment Polarity Gene Hedgehog

1995 • 191 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway

1996 • 176 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos

1993 • 172 citations

Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation

1995 • 165 citations

Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein

1995 • 162 citations

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

1990 • 151 citations

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

1995 • 145 citations

Distinct pathways for autocrine and paracrine Wingless signalling inDrosophila embryos

1994 • 121 citations

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

1993 • 112 citations

Restrictions to Floor Plate Induction by hedgehog and Winged-Helix Genes in the Neural Tube of Frog Embryos

1995 • 107 citations

Structure and expression of Hedgehog, a Drosophila segment-polarity gene required for cell-cell communication

1993 • 93 citations

Segment polarity genes and cell patterning within the Drosophila body segment

1991 • 81 citations

Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila

1995 • 76 citations

Serpentine Proteins Slither into the Wingless and Hedgehog Fields

1996 • 74 citations

Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage

1995 • 64 citations

Positional signal transmission in the developing chick limb

1981 • 55 citations

Complexity and versatility of the transcriptional response to cAMP

1994 • 43 citations

Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster

1993 • 38 citations

Morphogenetic Signalling: Responses to Hedgehog

1995 • 23 citations