Genomic Imprinting: Intricacies of Epigenetic Regulation in Clusters

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

2002 • 2,040 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

Dnmt3L and the Establishment of Maternal Genomic Imprints

2001 • 1,356 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

The non-coding Air RNA is required for silencing autosomal imprinted genes

2002 • 1,040 citations

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

2002 • 987 citations

Epigenetic Codes for Heterochromatin Formation and Silencing

2002 • 858 citations

Chromosomal silencing and localization are mediated by different domains of Xist RNA

2002 • 716 citations

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

1997 • 705 citations

Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene

2001 • 675 citations

GENOMIC IMPRINTING IN MAMMALS

1997 • 641 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

Genome Organization, Function, and Imprinting in Prader-Willi and Angelman Syndromes

2001 • 628 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization

2000 • 573 citations

Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation

2001 • 504 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1

2002 • 463 citations

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

2000 • 439 citations

Xist RNA and the Mechanism of X Chromosome Inactivation

2002 • 438 citations

Parental genomic imprinting of the human IGF2 gene

1993 • 422 citations

Methylation Dynamics of Imprinted Genes in Mouse Germ Cells

2002 • 420 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

Monoallelic expression of the human H19 gene

1992 • 409 citations

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome

1999 • 405 citations

The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A

2001 • 383 citations

RNA: Guiding Gene Silencing

2001 • 375 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

A 5′ 2-Kilobase-Pair Region of the Imprinted Mouse H19 Gene Exhibits Exclusive Paternal Methylation throughout Development

1997 • 341 citations

CTCF maintains differential methylation at the Igf2/H19 locus

2002 • 313 citations

Regulation of imprinted X-chromosome inactivation in mice by Tsix

2001 • 305 citations

Epimutations in Prader-Willi and Angelman Syndromes: A Molecular Study of 136 Patients with an Imprinting Defect

2003 • 304 citations

Beckwith-Wiedemann syndrome: imprinting in clusters revisited

2000 • 299 citations

A mouse model for Prader-Willi syndrome imprinting-centre mutations

1998 • 298 citations

IGF2 is parentally imprinted during human embryogenesis and in the Beckwith–Wiedemann syndrome

1993 • 290 citations

The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1

2000 • 280 citations

Disruption of Imprinted X Inactivation by Parent-of-Origin Effects at Tsix

2000 • 271 citations

CTCF, a Candidate Trans -Acting Factor for X-Inactivation Choice

2002 • 271 citations

X Inactivation in the Mouse Embryo Deficient for Dnmt1: Distinct Effect of Hypomethylation on Imprinted and Random X Inactivation

2000 • 265 citations

Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function

2000 • 255 citations

Stabilization of Xist RNA Mediates Initiation of X Chromosome Inactivation

1997 • 247 citations

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster

1998 • 245 citations

The insulin–like growth factor type–2 receptor gene is imprinted in the mouse but not in humans

1993 • 238 citations

LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids

1999 • 229 citations

Functional Polymorphism in the Parental Imprinting of the Human IGF2R Gene

1993 • 228 citations

Stopped at the border: boundaries and insulators

1999 • 222 citations

Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19

2002 • 219 citations

Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes

2002 • 214 citations

The Prader–Willi Syndrome Imprinting Center Activates the Paternally Expressed Murine Ube3a Antisense Transcript but Represses Paternal Ube3a

2001 • 205 citations

Maternal methylation imprints on human chromosome 15 are established during or after fertilization

2001 • 204 citations

Mechanisms of genomic imprinting

1999 • 203 citations

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern

1997 • 195 citations

Methylation-sensitive binding of transcription factor YY1 to an insulator sequence within the paternally expressed imprinted gene, Peg3

2003 • 191 citations

Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes

2001 • 180 citations

Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome

2000 • 178 citations

Parental imprinting of the human H19 gene

1992 • 176 citations

Histone H3 Lysine 9 Methylation Occurs Rapidly at the Onset of Random X Chromosome Inactivation

2002 • 174 citations

The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and theH19imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains

2003 • 167 citations

The IPL Gene on Chromosome 11p15.5 is Imprinted in Humans and Mice and is Similar to TDAG51, Implicated in Fas Expression and Apoptosis

1997 • 164 citations

An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus

2000 • 160 citations

Genomic imprinting — defusing the ovarian time bomb

1994 • 156 citations

Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos

2000 • 152 citations

A transcriptional insulator at the imprinted H19/Igf2 locus

2000 • 150 citations

X-chromosome inactivation: closing in on proteins that bind Xist RNA

2002 • 144 citations

Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting

2000 • 140 citations

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19

2000 • 139 citations

Epigenetic Aspects of X-Chromosome Dosage Compensation

2001 • 138 citations

DNA Methylation Is Linked to Deacetylation of Histone H3, but Not H4, on the Imprinted Genes Snrpnand U2af1-rs1

2001 • 135 citations

Evidence for the Role of PWCR1/HBII-85 C/D Box Small Nucleolar RNAs in Prader-Willi Syndrome

2002 • 132 citations

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer

2003 • 131 citations

Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice

2001 • 130 citations

Small Evolutionarily Conserved RNA, Resembling C/D Box Small Nucleolar RNA, Is Transcribed from PWCR1, a Novel Imprinted Gene in the Prader-Willi Deletion Region, Which Is Highly Expressed in Brain

2000 • 128 citations

Functional Analysis of the DXPas34 Locus, a 3′ Regulator of Xist Expression

1999 • 122 citations

Conservation of a maternal-specific methylation signal at the human IGF2R locus

1995 • 116 citations

The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice

2001 • 104 citations

Parent-Specific Complementary Patterns of Histone H3 Lysine 9 and H3 Lysine 4 Methylation at the Prader-Willi Syndrome Imprinting Center

2001 • 101 citations

Methylation Sequencing Analysis Refines the Region ofH19 Epimutation in Wilms Tumor

1999 • 100 citations

The 5′ flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer–promoter communication

2000 • 96 citations

The imprinting mechanism of the Prader-Willi/Angelman regional control center

2002 • 95 citations

A Differentially Methylated Imprinting Control Region within the Kcnq1 Locus Harbors a Methylation-sensitive Chromatin Insulator

2002 • 95 citations

Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch

2000 • 95 citations

Parent-of-Origin Specific Histone Acetylation and Reactivation of a Key Imprinted Gene Locus in Prader-Willi Syndrome

2000 • 83 citations

Analysis of Sequence Upstream of the Endogenous H19 Gene Reveals Elements Both Essential and Dispensable for Imprinting

2002 • 78 citations

Mouse Xist expression begins at zygotic genome activation and is timed by a zygotic clock

2001 • 76 citations

Distant cis-elements regulate imprinted expression of the mouse p57 Kip2 (Cdkn1c) gene: implications for the human disorder, Beckwith-Wiedemann syndrome

2001 • 73 citations

Loss of Xist Imprinting in Diploid Parthenogenetic Preimplantation Embryos

2001 • 72 citations

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation

2001 • 72 citations

Disruption of the Bipartite Imprinting Center in a Family with Angelman Syndrome

2001 • 71 citations

Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo

1997 • 70 citations

The chromosome 15 imprinting centre (IC) region has undergone multiple duplication events and contains an upstream exon of SNRPN that is deleted in all Angelman syndrome patients with an IC microdeletion

1999 • 65 citations

Bisulfite Genomic Sequencing-Derived Methylation Profile of theXistGene throughout Early Mouse Development

1998 • 65 citations

X-chromosome inactivation and the search for chromosome-wide silencers

2002 • 62 citations

Retrotransposed genes such as Frat3 in the mouse Chromosome 7C Prader-Willi syndrome region acquire the imprinted status of their insertion site

2001 • 58 citations

Tissue-Specific Imprinting of the Mouse Insulin-Like Growth Factor II Receptor Gene Correlates with Differential Allele-Specific DNA Methylation

1998 • 57 citations

In vivo Nuclease Hypersensitivity Studies Reveal Multiple Sites of Parental Origin-Dependent Differential Chromatin Conformation in the 150 Kb SNRPN Transcription Unit

1999 • 56 citations

Methylation profiles of DXPas34 during the onset of X-inactivation

2001 • 55 citations

Association of acetylated histones with paternally expressed genes in the Prader-Willi deletion region

2001 • 51 citations

Allelic IGF2R Repression Does Not Correlate with Expression of Antisense RNA in Human Extraembryonic Tissues

2001 • 51 citations

Establishment and Maintenance of DNA Methylation Patterns in Mouse Ndn: Implications for Maintenance of Imprinting in Target Genes of the Imprinting Center

2001 • 50 citations

Lack of Reciprocal Genomic Imprinting of Sense and Antisense RNA of Mouse Insulin-like Growth Factor II Receptor in the Central Nervous System1

1999 • 47 citations

Control of Xist expression for imprinted and random X chromosome inactivation in mice

2001 • 41 citations

An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus

2000 • 35 citations

Elucidation of the Minimal Sequence Required to Imprint H19 Transgenes

2001 • 29 citations

Genomic Imprinting in the Rat: Linkage ofIgf2andH19Genes and Opposite Parental Allele-Specific Expression during Embryogenesis

1997 • 26 citations

Imprinted methylation and its effect on expression of the mouse Zfp127 gene

1999 • 25 citations

Tissue-Specific Imprinting of the Mouse Insulin-Like Growth Factor II Receptor Gene Correlates with Differential Allele-Specific DNA Methylation

1998 • 19 citations

Absence of an Obvious Molecular Imprinting Mechanism in a Human Fetus with MonoallelicIGF2RExpression

1998 • 17 citations

Mouse Xist expression begins at zygotic genome activation and is timed by a zygotic clock

2002 • 7 citations