Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

1999 • 1,076 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1994 • 466 citations

Disruption of insulin–like growth factor 2 imprinting in Beckwith–Wiedemann syndrome

1993 • 427 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

Characterization of the chicken β-globin insulator

1997 • 381 citations

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

1997 • 349 citations

A 5′ 2-Kilobase-Pair Region of the Imprinted Mouse H19 Gene Exhibits Exclusive Paternal Methylation throughout Development

1997 • 341 citations

Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome

1997 • 325 citations

Imprinting mutations in the Beckwith—Wiedemann syndrome suggested by an altered imprinting pattern in the IGF2–H19 domain

1995 • 215 citations

Synthesis of microporous transition-metal-oxide molecular sieves by a supramolecular templating mechanism

1997 • 177 citations

Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.

1995 • 147 citations

Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith- Wiedemann syndrome

1997 • 126 citations

Location of enhancers is essential for the imprinting of H19 and Igf2 genes

1998 • 126 citations

A Novel cis -Regulatory Element, the PTS, Mediates an Anti-Insulator Activity in the Drosophila Embryo

1999 • 122 citations

Epigenetic changes at the insulin-like growth factor II/ H19 locus in developing kidney is an early event in Wilms tumorigenesis

1997 • 116 citations

Two regulatory domains flank the mouse H19 gene.

1988 • 110 citations

Methylation Sequencing Analysis Refines the Region ofH19 Epimutation in Wilms Tumor

1999 • 100 citations

Enhancer competition between H19 and Igf 2 does not mediate their imprinting

1999 • 93 citations

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus

1996 • 93 citations

Parental Allele-Specific Chromatin Configuration in a Boundary–Imprinting-Control Element Upstream of the Mouse H19 Gene

1999 • 83 citations

Chromatin conformation of the H19 epigenetic mark

1998 • 76 citations

Role of a 461-bp G-rich repetitive element in H19 transgene imprinting

1999 • 51 citations

A potential imprint control element: identification of a conserved 42 bp sequence upstream of H19

1999 • 48 citations

Characterization of Novel Parent-Specific Epigenetic Modifications Upstream of the Imprinted Mouse H19Gene

1998 • 45 citations