The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.

1998 • 964 citations

Maternal epigenetics and methyl supplements affectagoutigene expression inA^vy/amice

1998 • 851 citations

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

1997 • 702 citations

Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15

1995 • 606 citations

Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization

2000 • 573 citations

Imprinting in Prader–Willi and Angelman syndromes

1998 • 451 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome

2000 • 320 citations

[51] Gene targeting in embryonic stem cells

1993 • 320 citations

A mouse model for Prader-Willi syndrome imprinting-centre mutations

1998 • 298 citations

Imprinting-Mutation Mechanisms in Prader-Willi Syndrome

1999 • 276 citations

Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene

1996 • 257 citations

Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene.

1996 • 234 citations

The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and Mouse

1997 • 230 citations

Imprinting mutations suggested by abnormal DNA methylation patterns in familial Angelman and Prader-Willi syndromes.

1994 • 219 citations

Disruption of the mouse necdin gene results in early post-natal lethality

1999 • 207 citations

Maternal methylation imprints on human chromosome 15 are established during or after fertilization

2001 • 204 citations

Mechanisms of genomic imprinting

1999 • 203 citations

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern

1997 • 195 citations

An imprinted, mammalian bicistronic transcript encodes two independent proteins

1999 • 189 citations

Minimal definition of the imprinting center and fixation of chromosome 15q11-q13 epigenotype by imprinting mutations.

1996 • 176 citations

A candidate mouse model for Prader–Willi syndrome which shows an absence of Snrpn expression

1992 • 176 citations

Paternal Deletion from Snrpn to Ube3a in the Mouse Causes Hypotonia, Growth Retardation and Partial Lethality and Provides Evidence for a Gene Contributing to Prader-Willi Syndrome

1999 • 159 citations

Sporadic Imprinting Defects in Prader-Willi Syndrome and Angelman Syndrome: Implications for Imprint-Switch Models, Genetic Counseling, and Prenatal Diagnosis

1998 • 152 citations

De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch

2000 • 149 citations

Small Evolutionarily Conserved RNA, Resembling C/D Box Small Nucleolar RNA, Is Transcribed from PWCR1, a Novel Imprinted Gene in the Prader-Willi Deletion Region, Which Is Highly Expressed in Brain

2000 • 128 citations

Imprinting in Angelman and Prader-Willi syndromes

1998 • 127 citations

A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and Angelman syndromes

1999 • 121 citations

The imprinting box of the Prader-Willi/Angelman syndrome domain

2000 • 119 citations

An Imprinted Mouse Transcript Homologous to the Human Imprinted in Prader-Willi Syndrome (IPW) Gene

1997 • 105 citations

Towards a molecular understandingof Prader-Willi and Angelman syndromes

1999 • 103 citations

Recycling Selectable Markers in Mouse Embryonic Stem Cells

1996 • 97 citations

A 5-kb imprinting center deletion in a family with Angelman syndrome reduces the shortest region of deletion overlap to 880 bp

1999 • 96 citations

A complete YAC contig of the Prader-Willi/Angelman chromosome region (15q11–q13) and refined localization of the SNRPN gene

1993 • 94 citations

Breakage in the SNRPN locus in a balanced 46,XY,t(15;19) Prader-Willi syndrome patient

1996 • 83 citations

Exclusion of SNRPN as a major determinant of Prader-Willi syndrome by a translocation breakpoint

1996 • 83 citations

A previously unrecognised phenotype characterised by obesity, muscular hypotonia, and ability to speak in patients with Angelman syndrome caused by an imprinting defect

1999 • 82 citations

Prader-Willi Syndrome Is Caused by Disruption of the SNRPN Gene

1999 • 74 citations

The chromosome 15 imprinting centre (IC) region has undergone multiple duplication events and contains an upstream exon of SNRPN that is deleted in all Angelman syndrome patients with an IC microdeletion

1999 • 65 citations

Balanced Translocation 46, XY, t(2;15)(q37.2;q11.2) Associated with Atypical Prader-Willi Syndrome

1997 • 58 citations

Structure and function correlations at the imprinted mouse Snrpn locus

1998 • 40 citations

The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region.

1997 • 38 citations

The Mouse Necdin Gene Is Expressed from the Paternal Allele Only and Lies in the 7C Region of the Mouse Chromosome 7, a Region of Conserved Synteny to the Human Prader-Willi Syndrome Region

1997 • 31 citations

Analysis of murine Snrpn and human SNRPN gene imprinting in transgenic mice

1999 • 30 citations