The Prader–Willi Syndrome Imprinting Center Activates the Paternally Expressed Murine Ube3a Antisense Transcript but Represses Paternal Ube3a

Association Mapping in Structured Populations

2000 • 1,990 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

UBE3A/E6-AP mutations cause Angelman syndrome

1997 • 1,270 citations

Tsix, a gene antisense to Xist at the X-inactivation centre

1999 • 809 citations

Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15

1995 • 606 citations

Angelman and Prader‐Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion

1989 • 575 citations

Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization

2000 • 573 citations

Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons

1997 • 495 citations

Imprinting in Prader–Willi and Angelman syndromes

1998 • 451 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome

1999 • 405 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Speed congenics: a classic technique in the fast lane (relatively speaking)

1997 • 347 citations

A mouse model for Prader-Willi syndrome imprinting-centre mutations

1998 • 298 citations

Disruption of Imprinted X Inactivation by Parent-of-Origin Effects at Tsix

2000 • 271 citations

The Frequency of Uniparental Disomy in Prader-Willi Syndrome

1992 • 260 citations

The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region

1997 • 247 citations

Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader–Willi syndrome region

1992 • 243 citations

Identification of a novel paternally expressed gene in the Prader - Willi syndrome region

1994 • 243 citations

The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and Mouse

1997 • 230 citations

LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids

1999 • 229 citations

A Novel Imprinted Gene, Encoding a RING Zinc-Finger Protein, and Overlapping Antisense Transcript in the Prader-Willi Syndrome Critical Region

1999 • 225 citations

Imprinting mutations suggested by abnormal DNA methylation patterns in familial Angelman and Prader-Willi syndromes.

1994 • 219 citations

Mechanisms of genomic imprinting

1999 • 203 citations

The Human Magel2 Gene and Its Mouse Homologue Are Paternally Expressed and Mapped to the Prader-Willi Region

1999 • 183 citations

Minimal definition of the imprinting center and fixation of chromosome 15q11-q13 epigenotype by imprinting mutations.

1996 • 176 citations

An imprinted antisense transcript at the human GNAS1 locus

2000 • 165 citations

An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus

2000 • 160 citations

Genomic imprinting and uniparental disomy in Angelman and Prader‐Willi syndromes: A review

1993 • 159 citations

Paternal Deletion from Snrpn to Ube3a in the Mouse Causes Hypotonia, Growth Retardation and Partial Lethality and Provides Evidence for a Gene Contributing to Prader-Willi Syndrome

1999 • 159 citations

Sporadic Imprinting Defects in Prader-Willi Syndrome and Angelman Syndrome: Implications for Imprint-Switch Models, Genetic Counseling, and Prenatal Diagnosis

1998 • 152 citations

De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch

2000 • 149 citations

Small Evolutionarily Conserved RNA, Resembling C/D Box Small Nucleolar RNA, Is Transcribed from PWCR1, a Novel Imprinted Gene in the Prader-Willi Deletion Region, Which Is Highly Expressed in Brain

2000 • 128 citations

Imprinting of a RING Zinc-Finger Encoding Gene in the Mouse Chromosome Region Homologous to the Prader-Willi Syndrome Genetic Region

1999 • 110 citations

An Imprinted Mouse Transcript Homologous to the Human Imprinted in Prader-Willi Syndrome (IPW) Gene

1997 • 105 citations

Similar molecular deletions on chromosome 15q11.2 are encountered in both the Prader-Willi and Angelman syndromes

1988 • 97 citations

Molecular mechanisms in Angelman syndrome: a survey of 93 patients.

1993 • 75 citations

Balanced Translocation 46, XY, t(2;15)(q37.2;q11.2) Associated with Atypical Prader-Willi Syndrome

1997 • 58 citations

Imprinting of the mouse Igf2r gene depends on an intronic CpG island

1998 • 44 citations

DNA methylation patterns in human tissues of uniparental origin using a zinc-finger gene (ZNF127) from the Angelman/Prader-Willi region

1996 • 25 citations

Further examination of the Xist promoter-switch hypothesis in X inactivation: Evidence against the existence and function of a P ₀ promoter

1999 • 20 citations