Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts

1993 • 807 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

The Sins of the Fathers and Mothers

1999 • 489 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

An enhancer deletion affects both H19 and Igf2 expression.

1995 • 398 citations

Allele-specific replication timing of imprinted gene regions

1993 • 385 citations

The boundaries of the silenced HMR domain in Saccharomyces cerevisiae

1999 • 370 citations

Imprinting and the Initiation of Gene Silencing in the Germ Line

1998 • 359 citations

A 5′ 2-Kilobase-Pair Region of the Imprinted Mouse H19 Gene Exhibits Exclusive Paternal Methylation throughout Development

1997 • 341 citations

The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo

1991 • 312 citations

Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function

2000 • 255 citations

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster

1998 • 245 citations

Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.

1997 • 243 citations

Cohabitation of insulators and silencing elements in yeast subtelomeric regions

1999 • 239 citations

In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element

1990 • 202 citations

A Polycomb and GAGA Dependent Silencer Adjoins the Fab-7 Boundary in the Drosophila Bithorax Complex

1997 • 202 citations

Laboratory Protocols for Conditional Gene Targeting

1997 • 176 citations

Imprinting mechanisms in mammals

1998 • 173 citations

Asynchronous replication of imprinted genes is established in the gametes and maintained during development

1999 • 170 citations

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19

2000 • 139 citations

Location of enhancers is essential for the imprinting of H19 and Igf2 genes

1998 • 126 citations

A Novel cis -Regulatory Element, the PTS, Mediates an Anti-Insulator Activity in the Drosophila Embryo

1999 • 122 citations

Imprinting of Igf2 and H19 from a 130 kb YAC transgene

1997 • 108 citations

An imprinting element from the mouse H19 locus functions as a silencer in Drosophila

1997 • 106 citations

Igf2 imprinting does not require its own DNA methylation or H19 RNA

1998 • 101 citations

Simple and efficient production of embryonic stem cell-embryo chimeras by coculture.

1993 • 99 citations

Enhancer competition between H19 and Igf 2 does not mediate their imprinting

1999 • 93 citations

Parental Allele-Specific Chromatin Configuration in a Boundary–Imprinting-Control Element Upstream of the Mouse H19 Gene

1999 • 83 citations

A 5′ Differentially Methylated Sequence and the 3′-Flanking Region Are Necessary for H19 Transgene Imprinting

1997 • 77 citations

Chromatin conformation of the H19 epigenetic mark

1998 • 76 citations

Analysis of DNA Replication by Fluorescencein SituHybridization

1997 • 52 citations

Biallelic transcription of Igf2 and H19 in individual cells suggests a post-transcriptional contribution to genomic imprinting

1999 • 48 citations

A dominant positive and negative selectable gene for use in mammalian cells.

1991 • 45 citations

A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice

1999 • 44 citations

The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns

1998 • 41 citations

Identification of a silencing element in the human 15q11-q13 imprinting center by using transgenicDrosophila

1998 • 38 citations

Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb

2000 • 30 citations