Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation

Translating the Histone Code

2001 • 9,488 citations

The language of covalent histone modifications

2000 • 8,260 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

2001 • 1,685 citations

The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

1992 • 1,269 citations

Requirement for Xist in X chromosome inactivation

1996 • 995 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

Rb targets histone H3 methylation and HP1 to promoters

2001 • 892 citations

Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries

2001 • 746 citations

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

1997 • 705 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

X-chromosome inactivation: counting, choice and initiation

2001 • 678 citations

Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome

1991 • 617 citations

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals

1998 • 591 citations

A Shift from Reversible to Irreversible X Inactivation Is Triggered during ES Cell Differentiation

2000 • 552 citations

Targeted Mutagenesis of Tsix Leads to Nonrandom X Inactivation

1999 • 509 citations

Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation

2001 • 482 citations

The HP1 protein family: getting a grip on chromatin

2000 • 476 citations

X-Chromosome inactivation: a repeat hypothesis

1998 • 455 citations

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

1999 • 433 citations

Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes

2001 • 369 citations

A 450 kb Transgene Displays Properties of the Mammalian X-Inactivation Center

1996 • 315 citations

X Chromosome Inactivation Is Mediated by Xist RNA Stabilization

1997 • 294 citations

c-Myc target gene specificity is determined by a post-DNAbinding mechanism

1998 • 280 citations

Culture and differentiation of embryonic stem cells

1991 • 273 citations

Stabilization of Xist RNA Mediates Initiation of X Chromosome Inactivation

1997 • 247 citations

X-Inactivation and Histone H4 Acetylation in Embryonic Stem Cells

1996 • 244 citations

Conspiracy of silence among repeated transgenes

1998 • 231 citations

The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo

1999 • 220 citations

X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation

1985 • 208 citations

X-chromosome inactivation

1999 • 179 citations

Forty years of decoding the silence in X-chromosome inactivation

2001 • 177 citations

Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation

1998 • 168 citations

Histone Macroh2a1.2 Relocates to the Inactive X Chromosome after Initiation and Propagation of X-Inactivation

1999 • 166 citations

Biochemistry and biology of DNA methylation

1986 • 134 citations

Xist Yeast Artificial Chromosome Transgenes Function as X-Inactivation Centers Only in Multicopy Arrays and Not as Single Copies

1999 • 129 citations

Association and spreading of the Drosophila dosage compensation complex from a discrete roX1 chromatin entry site

2001 • 108 citations

Dynamic Relocalization of Histone Macroh2a1 from Centrosomes to Inactive X Chromosomes during X Inactivation

2000 • 92 citations

Promoter-specific hypoacetylation of X-inactivated genes

1999 • 87 citations

Reduced levels of histone H3 acetylation on the inactive X chromosome in human females

1996 • 82 citations

A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation

1999 • 73 citations

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation

2001 • 72 citations

The role of chromosomal RNAs in marking the X for dosage compensation

2000 • 44 citations

X chromosome inactivation: A hypothesis

1988 • 29 citations

Methylation of the PGK promoter region and an enhancer way-station model for X-chromosome inactivation.

1985 • 21 citations