Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

UBE3A/E6-AP mutations cause Angelman syndrome

1997 • 1,270 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

Requirement for Xist in X chromosome inactivation

1996 • 995 citations

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

1997 • 847 citations

Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse

1975 • 783 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

1997 • 753 citations

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

1997 • 705 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

GENOMIC IMPRINTING IN MAMMALS

1997 • 641 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15

1995 • 606 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

1997 • 496 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

1995 • 441 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

Disruption of insulin–like growth factor 2 imprinting in Beckwith–Wiedemann syndrome

1993 • 427 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

An enhancer deletion affects both H19 and Igf2 expression.

1995 • 398 citations

Allele-specific replication timing of imprinted gene regions

1993 • 385 citations

Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

1993 • 369 citations

Genomic imprinting of Mash2, a mouse gene required for trophoblast development

1995 • 366 citations

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements

1997 • 354 citations

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

1997 • 349 citations

Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome

1997 • 325 citations

Genomic imprinting of p57KIP2, a cyclin–dependent kinase inhibitor, in mouse

1995 • 288 citations

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

1993 • 271 citations

Physical linkage of two mammalian imprinted genes, H19 and insulin–like growth factor 2

1992 • 261 citations

Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene

1996 • 257 citations

Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.

1997 • 243 citations

Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader–Willi syndrome region

1992 • 243 citations

Identification of a novel paternally expressed gene in the Prader - Willi syndrome region

1994 • 243 citations

Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome

1997 • 237 citations

Normal Lymphocyte Development but Delayed Humoral Immune Response in CD81-null Mice

1997 • 231 citations

Functional Polymorphism in the Parental Imprinting of the Human IGF2R Gene

1993 • 228 citations

Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

1994 • 219 citations

Allele specificity of DNA replication timing in the Angelman/Prader–Willi syndrome imprinted chromosomal region

1994 • 195 citations

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern

1997 • 195 citations

Minimal definition of the imprinting center and fixation of chromosome 15q11-q13 epigenotype by imprinting mutations.

1996 • 176 citations

PARENTAL IMPRINTING AND HUMAN DISEASE

1996 • 170 citations

The IPL Gene on Chromosome 11p15.5 is Imprinted in Humans and Mice and is Similar to TDAG51, Implicated in Fas Expression and Apoptosis

1997 • 164 citations

Genomic imprinting: potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes

1997 • 150 citations

Low Frequency of p57KIP2 Mutation in Beckwith-Wiedemann Syndrome

1997 • 141 citations

Coding Mutations in p57 Are Present in Some Cases of Beckwith-Wiedemann Syndrome but Are Rare or Absent in Wilms Tumors

1997 • 140 citations

Imprinted chromosomal regions of the human genome display sex-specific meiotic recombination frequencies

1995 • 129 citations

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway

1996 • 127 citations

Location of enhancers is essential for the imprinting of H19 and Igf2 genes

1998 • 126 citations

Conservation of a maternal-specific methylation signal at the human IGF2R locus

1995 • 116 citations

Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors

1996 • 115 citations

Competition- a common motif for the imprinting mechanism?

1997 • 115 citations

Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments.

1995 • 108 citations

Tissue-specific and allele-specific replication timing control in the imprinted human Prader-Willi syndrome region.

1995 • 74 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 70 citations

A 1-Mb Physical Map and PAC Contig of the Imprinted Domain in 11p15.5 That Contains TAPA1 and the BWSCR1/WT2 Region

1997 • 66 citations

A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues

1996 • 59 citations

Epigenetic and Chromosomal Control of Gene Expression: Molecular and Genetic Analysis of X Chromosome Inactivation

1993 • 54 citations

A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues

1995 • 40 citations