Methylation Sequencing Analysis Refines the Region ofH19 Epimutation in Wilms Tumor

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

Relaxation of imprinted genes in human cancer

1993 • 792 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

1993 • 710 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1994 • 466 citations

Disruption of insulin–like growth factor 2 imprinting in Beckwith–Wiedemann syndrome

1993 • 427 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

Monoallelic expression of the human H19 gene

1992 • 409 citations

Imprinting and the Initiation of Gene Silencing in the Germ Line

1998 • 359 citations

A 5′ 2-Kilobase-Pair Region of the Imprinted Mouse H19 Gene Exhibits Exclusive Paternal Methylation throughout Development

1997 • 341 citations

Epigenetic lesions at the H19 locus in Wilms' tumour patients

1994 • 318 citations

IGF2 is parentally imprinted during human embryogenesis and in the Beckwith–Wiedemann syndrome

1993 • 290 citations

Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.

1997 • 243 citations

Imprinting mutations in the Beckwith—Wiedemann syndrome suggested by an altered imprinting pattern in the IGF2–H19 domain

1995 • 215 citations

Parental imprinting of the human H19 gene

1992 • 176 citations

DNA methylation in the Alu sequences of diploid and haploid primary human cells.

1993 • 175 citations

Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching.

1993 • 170 citations

Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.

1995 • 147 citations

Somatic overgrowth associated with overexpression of insulin–like growth factor II

1996 • 143 citations

Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression

1994 • 139 citations

Developmental differences in methylation of human Alu repeats.

1993 • 129 citations

Epigenetic changes at the insulin-like growth factor II/ H19 locus in developing kidney is an early event in Wilms tumorigenesis

1997 • 116 citations

Epigenetic modification and uniparental inheritance of H19 in Beckwith-Wiedemann syndrome.

1997 • 93 citations

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus

1996 • 93 citations

Allelic methylation of H19 and IGF2 in the Beckwith — Wiedemann syndrome

1994 • 87 citations

Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis.

1997 • 61 citations

A potential imprint control element: identification of a conserved 42 bp sequence upstream of H19

1999 • 48 citations