Human FOXP3 and cancer

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

2009 • 2,107 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Regulatory T Cells

2000 • 1,827 citations

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

2006 • 1,180 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

2006 • 1,118 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection

2007 • 1,060 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Tumor-Infiltrating FOXP3⁺ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

2008 • 926 citations

Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

2005 • 878 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

1989 • 760 citations

Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

2006 • 746 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

2009 • 667 citations

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

2007 • 661 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

2006 • 561 citations

Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 • 559 citations

Control of Regulatory T Cell Lineage Commitment and Maintenance

2009 • 557 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma

2006 • 491 citations

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

2006 • 474 citations

Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells

2005 • 453 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

CD4+CD25high T Cells Are Enriched in the Tumor and Peripheral Blood of Prostate Cancer Patients

2006 • 416 citations

Forkhead-box transcription factors and their role in the immune system

2004 • 404 citations

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

2007 • 394 citations

FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

2007 • 384 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

2009 • 355 citations

Epigenetic mechanisms of regulation of Foxp3 expression

2009 • 354 citations

Foxp3 Expression in Pancreatic Carcinoma Cells as a Novel Mechanism of Immune Evasion in Cancer

2007 • 338 citations

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

2009 • 307 citations

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 ⁺ Regulatory T Cells

2009 • 300 citations

Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells

2008 • 294 citations

FOXP3 Expression and Overall Survival in Breast Cancer

2009 • 293 citations

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

2008 • 288 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor

2006 • 267 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 258 citations

Regulatory T cells and treatment of cancer

2008 • 253 citations

Depletion of CD4⁺CD25⁺ human regulatory T cells in vivo: Kinetics of Treg depletion and alterations in immune functions in vivo and in vitro

2007 • 244 citations

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2

2007 • 242 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 231 citations

Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation

2006 • 230 citations

Isoform-Specific Inhibition of RORα-Mediated Transcriptional Activation by Human FOXP3

2008 • 229 citations

Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8+/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?

2008 • 220 citations

The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery

2007 • 217 citations

Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate

2009 • 210 citations

Tumor-Infiltrating Foxp3−CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma

2007 • 198 citations

Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based Vaccines

2006 • 188 citations

X-Chromosome Genetics and Human Cancer

2004 • 187 citations

The Regulatory T Cell–Associated Transcription Factor FoxP3 Is Expressed by Tumor Cells

2008 • 178 citations

Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo

2007 • 163 citations

Human Dendritic Cells Produce TGF-β1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+ Regulatory T Cells

2009 • 158 citations

Transient T cell depletion causes regression of melanoma metastases

2008 • 153 citations

Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine

2007 • 134 citations

Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy

2010 • 123 citations

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

2007 • 121 citations

Cutting Edge: Broad Expression of the FoxP3 Locus in Epithelial Cells: A Caution against Early Interpretation of Fatal Inflammatory Diseases following In Vivo Depletion of FoxP3-Expressing Cells

2008 • 118 citations

FOXP3 and NFAT: Partners in Tolerance

2006 • 113 citations

Low Dose Metronomic Oral Cyclophosphamide for Hormone Resistant Prostate Cancer: A Phase II Study

2007 • 111 citations

Immunogenic anti-cancer chemotherapy as an emerging concept

2008 • 100 citations

Denileukin diftitox: a novel immunotoxin

2009 • 96 citations

CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer

2008 • 64 citations

Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma

2008 • 61 citations

Foxp3 Expression in p53-dependent DNA Damage Responses

2010 • 59 citations

Domain Requirements and Sequence Specificity of DNA Binding for the Forkhead Transcription Factor FOXP3

2009 • 59 citations

The X Factor: Skewing X Inactivation towards Cancer

2007 • 30 citations

FOXP3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: poor correlation between different antibodies

2008 • 25 citations

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